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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1992-5-1
|
| pubmed:abstractText |
We have identified a dominant fetal thymocyte population at day 14.5 of gestation in the mouse that lacks CD4 and CD8 but expresses Fc gamma RII/III several days prior to acquisition of the T cell receptor (TCR) in vivo. If maintained in a thymic microenvironment, this population of CD4-CD8-TCR-Fc gamma RII/III+ thymocytes differentiates first into CD4+CD8+TCRlowFc gamma RII/III- thymocytes and subsequently CD4+CD8-TCRhighFc gamma RII/III- and CD4-CD8+TCRhighFc gamma RII/III- mature Ti alpha-beta lineage T cells. However, if removed from the thymus, the CD4-CD8-TCR-Fc gamma RII/III+ thymocyte population selectively generates functional natural killer (NK) cells in vivo as well as in vitro. These findings show that a cellular pool of Fc gamma RII/III+ precursors gives rise to T and NK lineages in a microenvironment-dependent manner. Moreover, they suggest a hitherto unrecognized role for Fc receptors on primitive T cells.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0092-8674
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
3
|
| pubmed:volume |
69
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
139-50
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:1532536-Animals,
pubmed-meshheading:1532536-Antigens, CD,
pubmed-meshheading:1532536-Antigens, Differentiation,
pubmed-meshheading:1532536-Base Sequence,
pubmed-meshheading:1532536-Cell Differentiation,
pubmed-meshheading:1532536-Cytotoxicity Tests, Immunologic,
pubmed-meshheading:1532536-Fetus,
pubmed-meshheading:1532536-Flow Cytometry,
pubmed-meshheading:1532536-Killer Cells, Natural,
pubmed-meshheading:1532536-Mice,
pubmed-meshheading:1532536-Mice, Inbred C57BL,
pubmed-meshheading:1532536-Molecular Sequence Data,
pubmed-meshheading:1532536-Phenotype,
pubmed-meshheading:1532536-Polymerase Chain Reaction,
pubmed-meshheading:1532536-Receptors, Fc,
pubmed-meshheading:1532536-Receptors, IgG,
pubmed-meshheading:1532536-T-Lymphocytes,
pubmed-meshheading:1532536-Thymus Gland
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
A population of early fetal thymocytes expressing Fc gamma RII/III contains precursors of T lymphocytes and natural killer cells.
|
| pubmed:affiliation |
Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|