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rdf:type |
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lifeskim:mentions |
umls-concept:C0026809,
umls-concept:C0030498,
umls-concept:C0205263,
umls-concept:C0231204,
umls-concept:C0321743,
umls-concept:C0332325,
umls-concept:C0443199,
umls-concept:C0591833,
umls-concept:C1515021,
umls-concept:C1704319,
umls-concept:C1817908
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pubmed:issue |
2
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pubmed:dateCreated |
1992-4-28
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pubmed:abstractText |
We have analysed the production of a wide variety of cytokines by in vitro concanavalin A (Con A) stimulated mesenteric lymph node cells (MLNC) from strains of mice experiencing chronic (B10.BR, AKR) versus acute (BALB/K) infection with the nematode parasite Trichuris muris. MLNC from infected BALB/K mice produced elevated levels of the Th2-specific cytokines interleukin-5 (IL-5) and IL-9. IL-3 and IL-4 remained at or just above normal. Interferon-gamma (IFN-gamma) (a Th1-type cytokine) was secreted only in small amounts. MLNC from infected susceptible B10.BR and AKR mice produced large amounts of IFN-gamma in the relative absence of IL-4 and IL-9. IL-5 levels failed to rise significantly above normal in B10.BR mice whilst in AKR mice high levels of IL-5 were detected early post-infection (p.i.) but levels decreased dramatically as the infection proceeded to reach normal levels by Day 34. IL-3 levels were depressed below normal. Our results are consistent with the polarization of the Th-cell response during T. muris infection to give predominantly IFN-gamma-secreting Th1 cells in strains of mice unable to expel the parasite and mainly IL-4, IL-5 and IL-9 producing Th2-type cells in resistant strains.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1532377-1824635,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1532377-1898663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1532377-1903765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1532377-1968485,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1532377-2040569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1532377-2188664,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1532377-2419430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1532377-2521244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1532377-2528896,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1532377-2531194,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1532377-2531779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1532377-2785556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1532377-2937061,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1532377-2937064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1532377-2948184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1532377-2960739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1532377-2960769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1532377-2967332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1532377-307029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1532377-3131876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1532377-3136419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1532377-3137580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1532377-3498768,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1532377-6048569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1532377-6409971,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1532377-6574462,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1532377-6604706,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1532377-7200084
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0019-2805
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
75
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
232-7
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1532377-Acute Disease,
pubmed-meshheading:1532377-Animals,
pubmed-meshheading:1532377-Chronic Disease,
pubmed-meshheading:1532377-Disease Susceptibility,
pubmed-meshheading:1532377-Immunity, Cellular,
pubmed-meshheading:1532377-Lymph Nodes,
pubmed-meshheading:1532377-Lymphokines,
pubmed-meshheading:1532377-Male,
pubmed-meshheading:1532377-Mice,
pubmed-meshheading:1532377-Mice, Inbred AKR,
pubmed-meshheading:1532377-Mice, Inbred BALB C,
pubmed-meshheading:1532377-Mice, Inbred Strains,
pubmed-meshheading:1532377-T-Lymphocyte Subsets,
pubmed-meshheading:1532377-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:1532377-Trichuriasis
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pubmed:year |
1992
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pubmed:articleTitle |
Cellular immune responses to the murine nematode parasite Trichuris muris. II. Differential induction of TH-cell subsets in resistant versus susceptible mice.
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pubmed:affiliation |
Department of Cell and Structural Biology, University of Manchester, U.K.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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