Linked Life Data

15322810

Source:http://linkedlifedata.com/resource/pubmed/id/15322810

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:15322810rdf:typepubmed:Citationlld:pubmed
pubmed-article:15322810lifeskim:mentionsumls-concept:C0026237lld:lifeskim
pubmed-article:15322810lifeskim:mentionsumls-concept:C0521447lld:lifeskim
pubmed-article:15322810lifeskim:mentionsumls-concept:C0037083lld:lifeskim
pubmed-article:15322810lifeskim:mentionsumls-concept:C0162772lld:lifeskim
pubmed-article:15322810lifeskim:mentionsumls-concept:C0017262lld:lifeskim
pubmed-article:15322810lifeskim:mentionsumls-concept:C1710082lld:lifeskim
pubmed-article:15322810lifeskim:mentionsumls-concept:C1704259lld:lifeskim
pubmed-article:15322810lifeskim:mentionsumls-concept:C0369760lld:lifeskim
pubmed-article:15322810lifeskim:mentionsumls-concept:C1705987lld:lifeskim
pubmed-article:15322810lifeskim:mentionsumls-concept:C1314939lld:lifeskim
pubmed-article:15322810lifeskim:mentionsumls-concept:C1709305lld:lifeskim
pubmed-article:15322810lifeskim:mentionsumls-concept:C0258018lld:lifeskim
pubmed-article:15322810pubmed:issue7lld:pubmed
pubmed-article:15322810pubmed:dateCreated2005-10-17lld:pubmed
pubmed-article:15322810pubmed:abstractTextCultured cells of tobacco (Nicotiana tabacum L. cv Petit Havana) were used to investigate signals regulating the expression of the "model" nuclear gene encoding the alternative oxidase (AOX) (AOX1), the terminal oxidase of the mitochondrial alternative respiratory pathway. Several conditions shown to induce AOX1 mRNA accumulation also result in an increase in cellular citrate concentrations, suggesting that citrate and/or other tricarboxylic acid (TCA) cycle intermediates may be important signal metabolites. In addition, mitochondrial reactive oxygen species (ROS) production has recently been shown to be a factor mediating mitochondria-to-nucleus signaling for the expression of AOX1. We found that the exogenously supplied TCA cycle organic acids citrate, malate and 2-oxoglutarate caused rapid and dramatic increases in the steady-state level of AOX1 mRNA at low, near physiological concentrations (0.1 mM). Furthermore, an increase in AOX1 induced by the addition of organic acids occurs independently of mitochondrial ROS formation. Our results demonstrate that two separate pathways for mitochondria-to-nucleus signaling of AOX1 may exist, one involving ROS and the other organic acids.lld:pubmed
pubmed-article:15322810pubmed:languageenglld:pubmed
pubmed-article:15322810pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15322810pubmed:citationSubsetIMlld:pubmed
pubmed-article:15322810pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15322810pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15322810pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15322810pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15322810pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15322810pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15322810pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15322810pubmed:statusMEDLINElld:pubmed
pubmed-article:15322810pubmed:monthDeclld:pubmed
pubmed-article:15322810pubmed:issn0721-7714lld:pubmed
pubmed-article:15322810pubmed:authorpubmed-author:GrayG RGRlld:pubmed
pubmed-article:15322810pubmed:authorpubmed-author:MaxwellD PDPlld:pubmed
pubmed-article:15322810pubmed:authorpubmed-author:McIntoshLLlld:pubmed
pubmed-article:15322810pubmed:authorpubmed-author:VillarimoA...lld:pubmed
pubmed-article:15322810pubmed:issnTypePrintlld:pubmed
pubmed-article:15322810pubmed:volume23lld:pubmed
pubmed-article:15322810pubmed:ownerNLMlld:pubmed
pubmed-article:15322810pubmed:authorsCompleteYlld:pubmed
pubmed-article:15322810pubmed:pagination497-503lld:pubmed
pubmed-article:15322810pubmed:dateRevised2011-11-17lld:pubmed
pubmed-article:15322810pubmed:meshHeadingpubmed-meshheading:15322810...lld:pubmed
pubmed-article:15322810pubmed:meshHeadingpubmed-meshheading:15322810...lld:pubmed
pubmed-article:15322810pubmed:meshHeadingpubmed-meshheading:15322810...lld:pubmed
pubmed-article:15322810pubmed:meshHeadingpubmed-meshheading:15322810...lld:pubmed
pubmed-article:15322810pubmed:meshHeadingpubmed-meshheading:15322810...lld:pubmed
pubmed-article:15322810pubmed:meshHeadingpubmed-meshheading:15322810...lld:pubmed
pubmed-article:15322810pubmed:meshHeadingpubmed-meshheading:15322810...lld:pubmed
pubmed-article:15322810pubmed:meshHeadingpubmed-meshheading:15322810...lld:pubmed
pubmed-article:15322810pubmed:meshHeadingpubmed-meshheading:15322810...lld:pubmed
pubmed-article:15322810pubmed:meshHeadingpubmed-meshheading:15322810...lld:pubmed
pubmed-article:15322810pubmed:meshHeadingpubmed-meshheading:15322810...lld:pubmed
pubmed-article:15322810pubmed:meshHeadingpubmed-meshheading:15322810...lld:pubmed
pubmed-article:15322810pubmed:meshHeadingpubmed-meshheading:15322810...lld:pubmed
pubmed-article:15322810pubmed:meshHeadingpubmed-meshheading:15322810...lld:pubmed
pubmed-article:15322810pubmed:meshHeadingpubmed-meshheading:15322810...lld:pubmed
pubmed-article:15322810pubmed:meshHeadingpubmed-meshheading:15322810...lld:pubmed
pubmed-article:15322810pubmed:meshHeadingpubmed-meshheading:15322810...lld:pubmed
pubmed-article:15322810pubmed:year2004lld:pubmed
pubmed-article:15322810pubmed:articleTitleMitochondria/nuclear signaling of alternative oxidase gene expression occurs through distinct pathways involving organic acids and reactive oxygen species.lld:pubmed
pubmed-article:15322810pubmed:affiliationDepartment of Plant Sciences, University of Saskatchewan, Saskatoon, SK, Canada, S7N 5A8. gr.gray@usask.calld:pubmed
pubmed-article:15322810pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15322810pubmed:publicationTypeResearch Support, U.S. Gov't, Non-P.H.S.lld:pubmed
pubmed-article:15322810pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15322810lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15322810lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15322810lld:pubmed