Linked Life Data

1532258

Source:http://linkedlifedata.com/resource/pubmed/id/1532258

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1992-4-21
pubmed:abstractText
Adrenalectomy predisposed the C3HeB/FeJ Mouse to tumor from a low dose of tumor cells, derived from a C3H spontaneous mammary adenocarcinoma. Sham surgery had a similar effect. In contrast, ovariectomized females, intact females, and male mice did not allow the low dose of cells to develop into a tumor. In order to better understand the role of hormones on the immune system controlling tumor growth, normal C3HeB/FeJ mice were studied for the effect of corticosterone or estradiol on splenic lymphocyte surface antigen expression. Adrenalectomy and ovariectomy caused a decrease in the percentage of all T cell subclasses and an increase in absolute numbers of immunoglobulin-bearing cells. Reconstitution of ovariectomized mice with estradiol did not significantly alter lymphocyte cell surface antigen expression. In contrast, injection of corticosterone into adrenalectomized mice brought these values to normal. Further study on normal mice placed on a 12:12-hr light:dark schedule showed that the hours after lights on (HALO) had a significant effect (analysis of variance) on body temperature, percentage of splenic B cells, T pan, T helper and T suppressor cells, and absolute numbers of T pan cells. Brain dehydroepiandrosterone sulfate correlated positively with T pan lymphocytes, but showed no significant effect on HALO. In contrast, body temperature showed a strong circadian rhythm (P less than 0.001). In addition, the presentation of estrus was circadian rhythmic (P = 0.003) with 58% of mice in estrus at 16 HALO and only 8% at 4 HALO. Multiple regression analysis revealed body temperature was strongly associated with absolute numbers of splenic T lymphocytes and their subsets, as well as percentage of B lymphocytes, Thy 1.2-, and Lyt-2-bearing cells. Similarly, HALO and estrous cycle stage were associated with percentage of T helper cells. The data showed that body temperature and hormones were associated with the cell surface antigens on lymphocytes and suggest that they affect lymphocyte function.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0037-9727
pubmed:author
pubmed:issnType
Print
pubmed:volume
199
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
432-40
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:1532258-Adenocarcinoma, pubmed-meshheading:1532258-Animals, pubmed-meshheading:1532258-Antigens, Surface, pubmed-meshheading:1532258-Body Temperature, pubmed-meshheading:1532258-Circadian Rhythm, pubmed-meshheading:1532258-Corticosterone, pubmed-meshheading:1532258-Dehydroepiandrosterone, pubmed-meshheading:1532258-Dehydroepiandrosterone Sulfate, pubmed-meshheading:1532258-Estradiol, pubmed-meshheading:1532258-Estrus, pubmed-meshheading:1532258-Female, pubmed-meshheading:1532258-Hormones, pubmed-meshheading:1532258-Light, pubmed-meshheading:1532258-Male, pubmed-meshheading:1532258-Mammary Neoplasms, Experimental, pubmed-meshheading:1532258-Mice, pubmed-meshheading:1532258-Mice, Inbred C3H, pubmed-meshheading:1532258-Spleen, pubmed-meshheading:1532258-T-Lymphocyte Subsets
pubmed:year
1992
pubmed:articleTitle
Surgical influence on murine immunity and tumor growth: relationship of body temperature and hormones with splenocytes.
pubmed:affiliation
Department of Life Sciences, IIT Research Institute, Chicago, Illinois 60616.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't