Source:http://linkedlifedata.com/resource/pubmed/id/15322553
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
2004-9-1
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| pubmed:databankReference | |
| pubmed:abstractText |
Vascular proliferative disorders, such as atherosclerosis and restenosis, are the most common causes of severe cardiovascular diseases, but a common molecular mechanism remains elusive. Here, we identify and characterize a novel hyperplasia suppressor gene, named HSG (later re-named rat mitofusin-2). HSG expression was markedly reduced in hyper-proliferative vascular smooth muscle cells (VSMCs) from spontaneously hypertensive rat arteries, balloon-injured Wistar Kyoto rat arteries, or ApoE-knockout mouse atherosclerotic arteries. Overexpression of HSG overtly suppressed serum-evoked VSMC proliferation in culture, and blocked balloon injury induced neointimal VSMC proliferation and restenosis in rat carotid arteries. The HSG anti-proliferative effect was mediated by inhibition of ERK/MAPK signalling and subsequent cell-cycle arrest. Deletion of the p21(ras) signature motif, but not the mitochondrial targeting domain, abolished HSG-induced growth arrest, indicating that rHSG-induced anti-proliferation was independent of mitochondrial fusion. Thus, rHSG functions as a cell proliferation suppressor, whereas dysregulation of rHSG results in proliferative disorders.
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
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| pubmed:issn |
1465-7392
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
6
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
872-83
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:15322553-Animals,
pubmed-meshheading:15322553-Arteriosclerosis,
pubmed-meshheading:15322553-Cardiovascular Diseases,
pubmed-meshheading:15322553-Cell Division,
pubmed-meshheading:15322553-Coronary Restenosis,
pubmed-meshheading:15322553-Gene Expression Regulation,
pubmed-meshheading:15322553-Humans,
pubmed-meshheading:15322553-MAP Kinase Signaling System,
pubmed-meshheading:15322553-Membrane Proteins,
pubmed-meshheading:15322553-Mice,
pubmed-meshheading:15322553-Mice, Knockout,
pubmed-meshheading:15322553-Mitochondrial Proteins,
pubmed-meshheading:15322553-Molecular Sequence Data,
pubmed-meshheading:15322553-Muscle, Smooth, Vascular,
pubmed-meshheading:15322553-Myocytes, Smooth Muscle,
pubmed-meshheading:15322553-Oncogene Protein p21(ras),
pubmed-meshheading:15322553-Rats
|
| pubmed:year |
2004
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| pubmed:articleTitle |
Dysregulation of HSG triggers vascular proliferative disorders.
|
| pubmed:affiliation |
The Institute of Cardiovascular Science & The Institute of Molecular Medicine, Peking University, Beijing 100083, China.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|