Linked Life Data

15321680

Source:http://linkedlifedata.com/resource/pubmed/id/15321680

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2004-8-23
pubmed:abstractText
The study was made of the antibacterial effects of three terpene alcohols on Staphylococcus aureus, focusing on the leakage of K+ ions and toxicity over time. The leakage of K+ ions was monitored continuously with a K+-electrode. Our results suggested that the terpene alcohols, namely, farnesol, nerolidol and plaunotol might act on cell membranes. The rank order of effectiveness, farnesol>nerolidol>plaunotol, was the same in the toxicity assay and in the examination of the leakage of K+ ions, when we considered the initial rate and the amount of leaked K+ ions. The rank order agreed with the results of a growth-inhibition assay reported previously. The antibacterial activity reflected the initial rate of leakage of K+ ions, suggesting that damage to cell membranes might be one of the major modes of action of these terpene alcohols. The results also demonstrated that the initial rate of leakage and the amount of leaked K+ ions are useful as indices of the antibacterial activities of hydrophobic compounds.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0378-1097
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
237
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
325-31
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
The antibacterial effects of terpene alcohols on Staphylococcus aureus and their mode of action.
pubmed:affiliation
Department of Microbiology, Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan. inoue@ac.shoyaku.ac.jp
pubmed:publicationType
Journal Article