Source:http://linkedlifedata.com/resource/pubmed/id/15321026
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2004-8-23
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pubmed:abstractText |
We evaluated the efficacy and safety of latanoprost eye drops once-weekly, compared to once-daily for improving patient compliance. Twenty (20) patients (11 women and 9 men), 12 with ocular hypertension and 8 with early glaucoma, were studied after washout of the antiglaucoma treatment. One (1) group was treated with latanoprost once-daily (control). The other group was treated once-weekly (study group). Intraocular pressure (IOP) was measured at baseline and on the 2nd, 4th, 6th, and 9th day after the last drop in the study group, and for 3 months on the same schedule thereafter. The mean baseline IOP was 24.3 +/- 3.9 mmHg in the study group (range, 18-29) and 24.4 +/- 4.4 mmHg in the control group (range, 17-32). The average IOP at all time points of post-treatment was 17.7 +/- 1.5 mmHg (range, 14-23) and 16.9 +/- 2.30 mmHg (range, 13-21), respectively. Latanoprost significantly lowered IOP in both groups (study group, p = 0.005; controls, p = 0.0019). The difference between post-treatment IOP was insignificant in both groups at each time point. The study group had fewer minor side effects than the control group (1/10 versus 6/10, respectively). Latanoprost treatment once-weekly was as effective, and bore fewer minor side effects, as once-daily treatment after 3 months of follow-up.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1080-7683
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
321-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15321026-Adult,
pubmed-meshheading:15321026-Aged,
pubmed-meshheading:15321026-Analysis of Variance,
pubmed-meshheading:15321026-Drug Administration Schedule,
pubmed-meshheading:15321026-Female,
pubmed-meshheading:15321026-Glaucoma,
pubmed-meshheading:15321026-Humans,
pubmed-meshheading:15321026-Intraocular Pressure,
pubmed-meshheading:15321026-Male,
pubmed-meshheading:15321026-Middle Aged,
pubmed-meshheading:15321026-Ocular Hypertension,
pubmed-meshheading:15321026-Patient Compliance,
pubmed-meshheading:15321026-Prostaglandins F, Synthetic,
pubmed-meshheading:15321026-Pruritus,
pubmed-meshheading:15321026-Statistics, Nonparametric
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pubmed:year |
2004
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pubmed:articleTitle |
The efficacy and safety of once-daily versus once-weekly latanoprost treatment for increased intraocular pressure.
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pubmed:affiliation |
Department of Ophthalmology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. kurtzs@inter.net.il
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Controlled Clinical Trial
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