| pubmed-article:15319774 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15319774 | lifeskim:mentions | umls-concept:C1527169 | lld:lifeskim |
| pubmed-article:15319774 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:15319774 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:15319774 | lifeskim:mentions | umls-concept:C0013018 | lld:lifeskim |
| pubmed-article:15319774 | lifeskim:mentions | umls-concept:C0032659 | lld:lifeskim |
| pubmed-article:15319774 | lifeskim:mentions | umls-concept:C0079459 | lld:lifeskim |
| pubmed-article:15319774 | lifeskim:mentions | umls-concept:C0229601 | lld:lifeskim |
| pubmed-article:15319774 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:15319774 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:15319774 | lifeskim:mentions | umls-concept:C0439662 | lld:lifeskim |
| pubmed-article:15319774 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:15319774 | pubmed:dateCreated | 2004-8-20 | lld:pubmed |
| pubmed-article:15319774 | pubmed:abstractText | A recent phase III trial comparing granulocyte colony-stimulating factor (G-CSF)-stimulated bone marrow (G-BM) and G-CSF-mobilized peripheral blood (G-PB) in matched sibling allograft recipients showed that G-BM produced a similar hematologic recovery but a reduced incidence of extensive chronic graft-versus-host disease, indicating differences in the cell populations infused. As a first step toward identifying these differences, we treated a group of healthy adult humans with 4 daily doses of G-CSF 10 microg/kg and monitored the effects on various hematopoietic and immune cell types in the PB and BM over 12 days. G-CSF treatment caused rapid and large but transient increases in the number of circulating CD34+ cells, colony-forming cells, and long-term culture-initiating cells and in the short-term repopulating activity detectable in nonobese diabetic/severe combined immunodeficiency/beta2-microglobulin-null mice. Similar but generally less marked changes occurred in the same cell populations in the BM. G-CSF also caused transient perturbations in some immune cell types in both PB and BM: these included a greater increase in the frequency of naive B cells and CD123+ dendritic cells in the BM. The rapidity of the effects of G-CSF on the early progenitor activity of the BM provides a rationale for the apparent equivalence in rates of hematologic recovery obtained with G-BM and G-PB allotransplants. Accompanying effects on immune cell populations are consistent with a greater ability of G-BM to promote tolerance in allogeneic recipients, and this could contribute to a lower rate of chronic graft-versus-host disease. | lld:pubmed |
| pubmed-article:15319774 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15319774 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15319774 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15319774 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15319774 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15319774 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15319774 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15319774 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:15319774 | pubmed:issn | 1083-8791 | lld:pubmed |
| pubmed-article:15319774 | pubmed:author | pubmed-author:PanzarellaTon... | lld:pubmed |
| pubmed-article:15319774 | pubmed:author | pubmed-author:SchultzKirk... | lld:pubmed |
| pubmed-article:15319774 | pubmed:author | pubmed-author:GilmanAndrewA | lld:pubmed |
| pubmed-article:15319774 | pubmed:author | pubmed-author:IssekutzAndre... | lld:pubmed |
| pubmed-article:15319774 | pubmed:author | pubmed-author:EavesConnie... | lld:pubmed |
| pubmed-article:15319774 | pubmed:author | pubmed-author:CoubanStephen... | lld:pubmed |
| pubmed-article:15319774 | pubmed:author | pubmed-author:ImrenSuzanS | lld:pubmed |
| pubmed-article:15319774 | pubmed:author | pubmed-author:SadekIreneI | lld:pubmed |
| pubmed-article:15319774 | pubmed:author | pubmed-author:ShierLuke RLR | lld:pubmed |
| pubmed-article:15319774 | pubmed:author | pubmed-author:ReganJillJ | lld:pubmed |
| pubmed-article:15319774 | pubmed:author | pubmed-author:LuoZhijuanZ | lld:pubmed |
| pubmed-article:15319774 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15319774 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:15319774 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15319774 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15319774 | pubmed:pagination | 624-34 | lld:pubmed |
| pubmed-article:15319774 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:15319774 | pubmed:meshHeading | pubmed-meshheading:15319774... | lld:pubmed |
| pubmed-article:15319774 | pubmed:meshHeading | pubmed-meshheading:15319774... | lld:pubmed |
| pubmed-article:15319774 | pubmed:meshHeading | pubmed-meshheading:15319774... | lld:pubmed |
| pubmed-article:15319774 | pubmed:meshHeading | pubmed-meshheading:15319774... | lld:pubmed |
| pubmed-article:15319774 | pubmed:meshHeading | pubmed-meshheading:15319774... | lld:pubmed |
| pubmed-article:15319774 | pubmed:meshHeading | pubmed-meshheading:15319774... | lld:pubmed |
| pubmed-article:15319774 | pubmed:meshHeading | pubmed-meshheading:15319774... | lld:pubmed |
| pubmed-article:15319774 | pubmed:meshHeading | pubmed-meshheading:15319774... | lld:pubmed |
| pubmed-article:15319774 | pubmed:meshHeading | pubmed-meshheading:15319774... | lld:pubmed |
| pubmed-article:15319774 | pubmed:meshHeading | pubmed-meshheading:15319774... | lld:pubmed |
| pubmed-article:15319774 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15319774 | pubmed:articleTitle | Differential effects of granulocyte colony-stimulating factor on marrow- and blood-derived hematopoietic and immune cell populations in healthy human donors. | lld:pubmed |
| pubmed-article:15319774 | pubmed:affiliation | Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada. | lld:pubmed |
| pubmed-article:15319774 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15319774 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15319774 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15319774 | lld:pubmed |
