Source:http://linkedlifedata.com/resource/pubmed/id/15319295
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
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| pubmed:dateCreated |
2004-12-1
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| pubmed:abstractText |
It has been shown that the matrix metalloproteinase (MMP)-1 promoter polymorphism 1G/2G is associated with an increased risk of developing various cancers including renal cell carcinoma (RCC), and is in linkage disequilibrium (LD) with the MMP-3 promoter polymorphism 5A/6A. These two genes are localized in 11q22 adjacent to each other. However, the relationship between the MMP-3 5A/6A polymorphism and susceptibility to cancer remains ambiguous. In this study, we genotyped eight polymorphisms in the region containing the MMP-1 and MMP-3 genes in 177 healthy subjects, and explored the relationships between RCC and these polymorphisms or haplotypes in 156 RCC cases and 230 age- and gender-matched controls. All the subjects studied were of Japanese descent. There were three polymorphisms that showed stronger LD with the MMP-1 1G/2G promoter variant than with the MMP-3 5A/6A promoter variant. One of these three polymorphisms was present in exon 2 of the MMP-3 gene and caused an amino acid change, Glu45Lys (G/A). When the genotype distribution of Glu45Lys was compared between RCC patients and controls, the frequency of the G/G genotype was significantly higher in the patients [age- and gender-adjusted odds ratio (OR) = 1.81, 95% confidence interval (CI) = 1.20-2.74]. A significant increase in the frequency of the 2G/2G genotype of the MMP-1 1G/2G polymorphism was also observed in the patients (age- and gender-adjusted OR = 1.86, CI = 1.23-2.82), whereas there was no significant difference for the MMP-3 5A/6A polymorphism. As expected based on these genotype-level results, the frequency of the 2G-G haplotype of MMP-1 1G/2G and MMP-3 Glu45Lys (G/A) polymorphisms was significantly higher in the patients than in the controls (crude OR = 1.95, CI = 1.31-2.91). These findings suggest that this haplotype of MMP-1 and MMP-3 variants may be associated with the risk of developing RCC.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
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| pubmed:issn |
0143-3334
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
25
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
2379-84
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:15319295-Adult,
pubmed-meshheading:15319295-Aged,
pubmed-meshheading:15319295-Aged, 80 and over,
pubmed-meshheading:15319295-Carcinoma, Renal Cell,
pubmed-meshheading:15319295-Case-Control Studies,
pubmed-meshheading:15319295-Female,
pubmed-meshheading:15319295-Genetic Predisposition to Disease,
pubmed-meshheading:15319295-Genotype,
pubmed-meshheading:15319295-Haplotypes,
pubmed-meshheading:15319295-Humans,
pubmed-meshheading:15319295-Japan,
pubmed-meshheading:15319295-Kidney,
pubmed-meshheading:15319295-Kidney Neoplasms,
pubmed-meshheading:15319295-Linkage Disequilibrium,
pubmed-meshheading:15319295-Male,
pubmed-meshheading:15319295-Matrix Metalloproteinase 1,
pubmed-meshheading:15319295-Matrix Metalloproteinase 3,
pubmed-meshheading:15319295-Middle Aged,
pubmed-meshheading:15319295-Odds Ratio,
pubmed-meshheading:15319295-Polymerase Chain Reaction,
pubmed-meshheading:15319295-Polymorphism, Genetic,
pubmed-meshheading:15319295-Promoter Regions, Genetic,
pubmed-meshheading:15319295-Risk Factors
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| pubmed:year |
2004
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| pubmed:articleTitle |
Association of a haplotype of matrix metalloproteinase (MMP)-1 and MMP-3 polymorphisms with renal cell carcinoma.
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| pubmed:affiliation |
Department of Urology, Yamaguchi University School of Medicine, Yamaguchi, Japan.
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| pubmed:publicationType |
Journal Article,
Comparative Study
|