|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0005821,
umls-concept:C0011209,
umls-concept:C0013227,
umls-concept:C0030685,
umls-concept:C0032521,
umls-concept:C0205369,
umls-concept:C0391871,
umls-concept:C0439590,
umls-concept:C0441712,
umls-concept:C0450442,
umls-concept:C0680255,
umls-concept:C0936012,
umls-concept:C1283071,
umls-concept:C1963578
|
|
pubmed:issue |
7
|
|
pubmed:dateCreated |
2004-8-20
|
|
pubmed:abstractText |
The in vitro aqueous behaviour of a metacryloyloxyethyl [2-(acetyloxy)-4-(trifluoromethyl)]benzoate (THEMA)/N,N'-dimethylacrylamide (DMA) copolymer with a THEMA molar content of 39% (labeled THDMA39) has been investigated. This composition has been selected to achieve a system able to keep both the non-water solubility during the release and the resorbability (and the water solubility) after the completion of the drug release. This copolymer exhibited, at pH 7.4, a constant release during several months, very interesting for a long term treatments required for the application of some cardiovascular devices. A kinetic model has been developed to explain the pseudo-zero-order kinetics of the release process. This model, which considers (from the aqueous studies) a linear increase with time of the amount of water present in the polymeric matrix, has been able to fit adequately the experimental data.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3-trifluoromethylbenzoate,
http://linkedlifedata.com/resource/pubmed/chemical/Acrylamides,
http://linkedlifedata.com/resource/pubmed/chemical/Biocompatible Materials,
http://linkedlifedata.com/resource/pubmed/chemical/Free Radicals,
http://linkedlifedata.com/resource/pubmed/chemical/Platelet Aggregation Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Polymers,
http://linkedlifedata.com/resource/pubmed/chemical/Salicylates,
http://linkedlifedata.com/resource/pubmed/chemical/Thrombin,
http://linkedlifedata.com/resource/pubmed/chemical/Toluene,
http://linkedlifedata.com/resource/pubmed/chemical/Water,
http://linkedlifedata.com/resource/pubmed/chemical/methacrylamide,
http://linkedlifedata.com/resource/pubmed/chemical/triflusal
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0920-5063
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
15
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
917-28
|
|
pubmed:dateRevised |
2008-2-20
|
|
pubmed:meshHeading |
pubmed-meshheading:15318801-Acrylamides,
pubmed-meshheading:15318801-Biocompatible Materials,
pubmed-meshheading:15318801-Blood Platelets,
pubmed-meshheading:15318801-Drug Design,
pubmed-meshheading:15318801-Free Radicals,
pubmed-meshheading:15318801-Humans,
pubmed-meshheading:15318801-Hydrogen-Ion Concentration,
pubmed-meshheading:15318801-Hydrolysis,
pubmed-meshheading:15318801-Kinetics,
pubmed-meshheading:15318801-Magnetic Resonance Spectroscopy,
pubmed-meshheading:15318801-Models, Chemical,
pubmed-meshheading:15318801-Platelet Aggregation,
pubmed-meshheading:15318801-Platelet Aggregation Inhibitors,
pubmed-meshheading:15318801-Polymers,
pubmed-meshheading:15318801-Salicylates,
pubmed-meshheading:15318801-Thrombin,
pubmed-meshheading:15318801-Time Factors,
pubmed-meshheading:15318801-Toluene,
pubmed-meshheading:15318801-Water
|
|
pubmed:year |
2004
|
|
pubmed:articleTitle |
Polymeric drugs with prolonged sustained delivery of specific anti-aggregant agents for platelets: kinetic analysis of the release mechanism.
|
|
pubmed:affiliation |
Instituto de Ciencia y Tecnología de Polímeros, CSIC, Juan de la Cierva 3, 28006 Madrid, Spain. gallardo@ictp.csic.es
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
