Linked Life Data

15316471

Source:http://linkedlifedata.com/resource/pubmed/id/15316471

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2004-8-18
pubmed:abstractText
During maxillary permanent canine eruption, the deciduous canine root is selectively resorbed while the adjacent permanent lateral incisor root is left intact. An understanding of this selective resorption could provide insights into the cause of moderate to severe iatrogenic root resorption during orthodontic tooth movement. This study investigated the possible role of extracellular matrix (ECM) proteins in the selective resorption process. The spatial expression patterns of 2 ECM proteins, osteopontin (OPN) and bone sialoprotein (BSP), were assessed within the periodontal ligament (PDL) surrounding root surface areas of deciduous and permanent teeth. Intact and resorbed root surface areas from 14 deciduous roots and intact root surface areas from 12 permanent tooth roots were examined. In the deciduous roots, BSP and OPN were locally expressed in the cell layer adjacent to the root surface and most intensely concentrated in areas surrounding and within odontoclasts proximal to the resorptive lacunae. In contrast, BSP and OPN were expressed in a generalized pattern throughout the PDL of permanent roots. These preliminary findings suggest a differential expression of ECM proteins on deciduous versus permanent tooth roots, which could act as a signal for selective odontoclast adhesion to, and subsequent resorption of, deciduous root surfaces.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
D
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0889-5406
pubmed:author
pubmed:issnType
Print
pubmed:volume
126
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
173-7
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Root resorption: the possible role of extracellular matrix proteins.
pubmed:affiliation
Department of Orthodontics, University of Iowa, Iowa City 52242, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't