Source:http://linkedlifedata.com/resource/pubmed/id/15315425
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
33
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| pubmed:dateCreated |
2004-8-18
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| pubmed:abstractText |
The cross-coupling of alkylzinc halides with alpha-chloroketones catalyzed by Cu(acac)2 is described. Using this method, primary and secondary alkyl groups are introduced adjacent to a ketone carbonyl under mild reaction conditions and in good yield. Cyclic, acyclic, aromatic, and aliphatic alpha-chloroketones are suitable substrates. Optically active alpha-chloroketones are converted to optically active products. The reaction was found to proceed stereospecifically with inversion of stereochemistry. The reaction is proposed to occur by direct substitution of the chloride with the alkyl group of an organocopper, -magnesium, or -zinc species.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:status |
PubMed-not-MEDLINE
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| pubmed:month |
Aug
|
| pubmed:issn |
0002-7863
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
25
|
| pubmed:volume |
126
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
10240-1
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| pubmed:dateRevised |
2008-1-17
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| pubmed:year |
2004
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| pubmed:articleTitle |
Catalytic cross-coupling of alkylzinc halides with alpha-chloroketones.
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| pubmed:affiliation |
Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390-9038, USA.
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| pubmed:publicationType |
Journal Article
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