Linked Life Data

15313894

Source:http://linkedlifedata.com/resource/pubmed/id/15313894

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
16
pubmed:dateCreated
2004-8-17
pubmed:abstractText
Sézary syndrome (Sz) is a malignancy of CD4+ memory skin-homing T cells and presents with erythroderma, lymphadenopathy, and peripheral blood involvement. To gain more insight into the molecular features of Sz, oligonucleotide array analysis was performed comparing gene expression patterns of CD4+ T cells from peripheral blood of patients with Sz with those of patients with erythroderma secondary to dermatitis and healthy controls. Using unsupervised hierarchical clustering gene, expression patterns of T cells from patients with Sz were classified separately from those of benign T cells. One hundred twenty-three genes were identified as significantly differentially expressed and had an average fold change exceeding 2. T cells from patients with Sz demonstrated decreased expression of the following hematopoietic malignancy-linked tumor suppressor genes: TGF-beta receptor II, Mxi1, Riz1, CREB-binding protein, BCL11a, STAT4, and Forkhead Box O1A. Moreover, the tyrosine kinase receptor EphA4 and the potentially oncogenic transcription factor Twist were highly and selectively expressed in T cells of patients with Sz. High expression of EphA4 and Twist was also observed in lesional skin biopsy specimens of a subset of patients with cutaneous T cell lymphomas related to Sz, whereas their expression was nearly undetectable in benign T cells or in skin lesions of patients with inflammatory dermatoses. Detection of EphA4 and Twist may be used in the molecular diagnosis of Sz and related cutaneous T-cell lymphomas. Furthermore, the membrane-bound EphA4 receptor may serve as a target for directed therapeutic intervention.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0008-5472
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
64
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5578-86
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:15313894-Female, pubmed-meshheading:15313894-Gene Expression Profiling, pubmed-meshheading:15313894-Gene Expression Regulation, Enzymologic, pubmed-meshheading:15313894-Gene Expression Regulation, Neoplastic, pubmed-meshheading:15313894-Humans, pubmed-meshheading:15313894-Male, pubmed-meshheading:15313894-Middle Aged, pubmed-meshheading:15313894-Nuclear Proteins, pubmed-meshheading:15313894-Oligonucleotide Array Sequence Analysis, pubmed-meshheading:15313894-Receptor, EphA4, pubmed-meshheading:15313894-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:15313894-Sezary Syndrome, pubmed-meshheading:15313894-Skin Neoplasms, pubmed-meshheading:15313894-T-Lymphocytes, pubmed-meshheading:15313894-Transcription Factors, pubmed-meshheading:15313894-Twist Transcription Factor
pubmed:year
2004
pubmed:articleTitle
Aberrant expression of the tyrosine kinase receptor EphA4 and the transcription factor twist in Sézary syndrome identified by gene expression analysis.
pubmed:affiliation
Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands.
pubmed:publicationType
Journal Article