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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1992-3-17
|
| pubmed:abstractText |
To improve the pharmacological characterization of the receptors mediating 5-hydroxytryptamine (5-HT)-induced apnea the inhibitory effects of exogenous 5-HT on respiration and phrenic nerve activity (PNA) were studied in anesthetized rats. The effects of putative 5-HT receptor agonists and antagonists on respiratory parameters were examined. During spontaneous respiration the bolus i.v. injection of 5-HT (3.125-25 micrograms/kg) produced a transient apnea, the duration of which increased in a dose-related manner. In addition, during artificial respiration 5-HT produced a silent response of PNA, the duration of which increased dose-dependently. These responses were significantly antagonized by GR38032F, a selective 5-HT3 receptor antagonist. Ketanserin (100 micrograms/kg) and methysergide (100 micrograms/kg), 5-HT2 receptor antagonists, also inhibited the 5-HT-induced apnea. These effects of 5-HT on respiration were mimicked by 2-methyl-5-HT (3.125-25 micrograms/kg), a selective 5-HT3 receptor agonist, and by a high dose of alpha-methyl-5-HT, a 5-HT2 receptor agonist, but not by 5-carboxamidotryptamine, a 5-HT1-like receptor agonist. Lung compliance was greatly reduced and lung resistance greatly increased by 5-HT (3.125-25 micrograms/kg). The 5-HT-induced changes in lung compliance and lung resistance were antagonized markedly by both ketanserin (100 micrograms/kg) and methysergide (100 micrograms/kg), but not by GR38032F (100 micrograms/kg). Bilateral vagotomy above the nodose ganglia completely prevented both the changes in PNA and the apnea induced by 5-HT. These actions of 5-HT were not prevented, however, by cervical vagotomy below the level of the nodose ganglion. On the other hand, this cervical vagotomy completely blocked the alpha-methyl-5-HT-induced apnea.(ABSTRACT TRUNCATED AT 250 WORDS)
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Imidazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Ketanserin,
http://linkedlifedata.com/resource/pubmed/chemical/Methysergide,
http://linkedlifedata.com/resource/pubmed/chemical/Ondansetron,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Antagonists
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0022-3565
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
260
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
917-24
|
| pubmed:dateRevised |
2003-11-14
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| pubmed:meshHeading |
pubmed-meshheading:1531363-Anesthesia,
pubmed-meshheading:1531363-Animals,
pubmed-meshheading:1531363-Apnea,
pubmed-meshheading:1531363-Bronchoconstriction,
pubmed-meshheading:1531363-Drug Interactions,
pubmed-meshheading:1531363-Imidazoles,
pubmed-meshheading:1531363-Ketanserin,
pubmed-meshheading:1531363-Male,
pubmed-meshheading:1531363-Methysergide,
pubmed-meshheading:1531363-Ondansetron,
pubmed-meshheading:1531363-Phrenic Nerve,
pubmed-meshheading:1531363-Rats,
pubmed-meshheading:1531363-Rats, Inbred Strains,
pubmed-meshheading:1531363-Respiration,
pubmed-meshheading:1531363-Respiratory Function Tests,
pubmed-meshheading:1531363-Serotonin,
pubmed-meshheading:1531363-Serotonin Antagonists,
pubmed-meshheading:1531363-Vagotomy
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| pubmed:year |
1992
|
| pubmed:articleTitle |
Pharmacological characterization of 5-hydroxytryptamine-induced apnea in the rat.
|
| pubmed:affiliation |
First Department of Pharmacology, Hokkaido University School of Medicine, Sapporo, Japan.
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| pubmed:publicationType |
Journal Article
|