15312991

Source:http://linkedlifedata.com/resource/pubmed/id/15312991

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0085104, umls-concept:C0449445, umls-concept:C2347946
pubmed:issue	3
pubmed:dateCreated	2004-8-17
pubmed:abstractText	Due to advances in chronobiology, chronopharmacology, and global market constraints, the traditional goal of pharmaceutics (e.g. design drug delivery systems with a constant drug release rate) is becoming obsolete. However, the major bottleneck in the development of drug delivery systems that match the circadian rhythm (chronopharmaceutical drug delivery systems: ChrDDS) may be the availability of appropriate technology. The last decade has witnessed the emergence of ChrDDS against several diseases. The increasing research interest surrounding ChrDDS may lead to the creation of a new sub-discipline in pharmaceutics known as chronopharmaceutics. This review introduces the concept of chronopharmaceutics, addresses theoretical/formal approaches to this sub-discipline, underscores potential disease-targets, revisits existing technologies and examples of ChrDDS. Future development in chronopharmaceutics may be made at the interface of other emerging disciplines such as system biology and nanomedicine. Such novel and more biological approaches to drug delivery may lead to safer and more efficient disease therapy in the future.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8607908
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Aug
pubmed:issn	0168-3659
pubmed:author	pubmed-author:YouanBi-Botti CBB
pubmed:issnType	Print
pubmed:day	27
pubmed:volume	98
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	337-53
pubmed:dateRevised	2006-11-15
pubmed:meshHeading	pubmed-meshheading:15312991-Animals, pubmed-meshheading:15312991-Chemistry, Pharmaceutical, pubmed-meshheading:15312991-Drug Delivery Systems, pubmed-meshheading:15312991-Drug Design, pubmed-meshheading:15312991-Humans, pubmed-meshheading:15312991-Pharmacokinetics
pubmed:year	2004
pubmed:articleTitle	Chronopharmaceutics: gimmick or clinically relevant approach to drug delivery?
pubmed:affiliation	Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center School of Pharmacy, Amarillo 1300, Coulter, TX 79106, USA. bcyouan@ama.ttuhsc.edu
pubmed:publicationType	Journal Article, Review, Research Support, Non-U.S. Gov't