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rdf:type |
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|
lifeskim:mentions |
|
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pubmed:issue |
5
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pubmed:dateCreated |
2004-12-13
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pubmed:abstractText |
Many studies have been published that report an association between thymidylate synthase (TS) and response to fluoropyrimidine-based chemotherapy and the overall outcome of patients with gastrointestinal cancer. The results have given rise to the possibility that, by determination of TS levels, the physician may decide if the patient has a potential benefit from fluoropyrimidine-based treatment, similar to measurements of oestrogen receptors in breast cancer. The purpose of this review is to summarize critically the reports on TS measurement in gastrointestinal cancer, focusing on the adjuvant fluoropyrimidine treatment situation.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1435-2443
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
389
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
405-13
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:15309542-Antimetabolites, Antineoplastic,
pubmed-meshheading:15309542-Chemotherapy, Adjuvant,
pubmed-meshheading:15309542-Clinical Trials as Topic,
pubmed-meshheading:15309542-Combined Modality Therapy,
pubmed-meshheading:15309542-Drug Resistance, Neoplasm,
pubmed-meshheading:15309542-Fluorouracil,
pubmed-meshheading:15309542-Gastrointestinal Neoplasms,
pubmed-meshheading:15309542-Humans,
pubmed-meshheading:15309542-Immunoblotting,
pubmed-meshheading:15309542-Immunohistochemistry,
pubmed-meshheading:15309542-Meta-Analysis as Topic,
pubmed-meshheading:15309542-Neoplasm Recurrence, Local,
pubmed-meshheading:15309542-Palliative Care,
pubmed-meshheading:15309542-Pancreatic Neoplasms,
pubmed-meshheading:15309542-Prognosis,
pubmed-meshheading:15309542-RNA, Messenger,
pubmed-meshheading:15309542-Survival Analysis,
pubmed-meshheading:15309542-Tegafur,
pubmed-meshheading:15309542-Thymidylate Synthase,
pubmed-meshheading:15309542-Treatment Outcome
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pubmed:year |
2004
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|
pubmed:articleTitle |
Thymidylate synthase expression and prognosis of patients with gastrointestinal cancers receiving adjuvant chemotherapy: a review.
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pubmed:affiliation |
Department of Visceral and Transplantation Surgery, University of Ulm, Steinhoevelstrasse 9, 89075 Ulm, Germany.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Review
|
