Linked Life Data

15309479

Source:http://linkedlifedata.com/resource/pubmed/id/15309479

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2004-11-30
pubmed:abstractText
To compare the role of nitric oxide in an adaptive process to chronic hypoxia, we examined the effects of endogenous nitric oxide synthase inhibition on pulmonary vascular tone in conscious sheep and pigs living at high altitude. Unanesthetized male sheep (n = 6) and pigs (n = 5), born and residing in the highlands of Qinghai Province, China (2,300-3,000 m a.s.l.) were studied at that altitude. Pulmonary artery pressure (P(pa)), pulmonary artery wedge pressure (P(cwp)), and cardiac output (CO) were measured. Pulmonary vascular resistance (PVR) was calculated as (P(pa)- P(cwp))/ CO. Using a climatic chamber, hemodynamic measurements during exposures to atmospheric pressures corresponding to altitudes of 0, 2,300, and 4,500 m a.s.l. were performed with and without NO inhibition, using N(w)-nitro- L-argine (NLA; 20 mg kg(-1)), a potent stereospecific competitive inhibitor of nitric oxide synthase. P(pa) and PVR at baseline (2,300 m) and during hypoxic exposure (4,500 m) were significantly higher in pigs than in sheep. After NLA administration, P(pa) increased and CO decreased in both animals, resulting in significantly increased PVR at baseline and during hypoxic exposure. However, there were no significant differences in the percent increase in basal or hypoxic PVR after NLA administration between sheep and pigs. We conclude that augmented endogenous NO production could contribute to the regulation of pulmonary vascular tone at high altitude in sheep and pigs. However, it is unlikely that NO is responsible for the different pulmonary vascular tones between sheep and pigs at basal condition at moderately high altitude.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0174-1578
pubmed:author
pubmed:issnType
Print
pubmed:volume
174
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
549-54
pubmed:dateRevised
2009-6-8
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Comparison of pulmonary vascular response to endogenous nitric oxide inhibition in sheep and pigs living at 2,300 m.
pubmed:affiliation
First Department of Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, 390-8621, Nagano, Matsumoto, Japan.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't