|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0005516,
umls-concept:C0008643,
umls-concept:C0008651,
umls-concept:C0031653,
umls-concept:C0034493,
umls-concept:C0035696,
umls-concept:C0086418,
umls-concept:C0162326,
umls-concept:C0205197,
umls-concept:C0205250,
umls-concept:C0439851,
umls-concept:C1283195,
umls-concept:C1552596,
umls-concept:C1882417,
umls-concept:C1947931
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
1992-2-12
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
A cDNA clone encoding the mRNA for the highly polymorphic human enzyme phosphoglucomutase 1 (PGM1; EC 5.4.2.2) has been isolated and characterized. This was achieved indirectly by first isolating a rabbit cDNA from an expression library using anti-rabbit PGM antibodies. A comparison of the nucleotide sequences shows that the homologies between human and rabbit PGM1 mRNAs are 92% and 97% for the coding nucleotide sequence and the amino acid sequence, respectively. The derived rabbit amino acid sequence is in complete agreement with the published protein sequence for rabbit muscle PGM. A physical localization of the human PGM1 gene to chromosome 1p31 has been determined by in situ hybridization. Analysis of DNA from a wide variety of vertebrates indicates a high level of PGM1 sequence conservation during evolution.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1530890-14235665,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1530890-1840235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1530890-1981504,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1530890-2037294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1530890-2143652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1530890-2294592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1530890-2527794,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1530890-2574561,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1530890-2676387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1530890-271968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1530890-2822696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1530890-3000276,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1530890-3023066,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1530890-3482146,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1530890-4656768,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1530890-4829444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1530890-496384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1530890-5476665,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1530890-5493845,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1530890-5493846,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1530890-6207203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1530890-6216484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1530890-6223925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1530890-6235151,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1530890-6329026,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1530890-6461922,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1530890-6961883
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0027-8424
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
89
|
|
pubmed:geneSymbol |
PGM1
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
411-5
|
|
pubmed:dateRevised |
2010-9-7
|
|
pubmed:meshHeading |
pubmed-meshheading:1530890-Animals,
pubmed-meshheading:1530890-Base Sequence,
pubmed-meshheading:1530890-Blotting, Southern,
pubmed-meshheading:1530890-Chromosome Banding,
pubmed-meshheading:1530890-Chromosome Mapping,
pubmed-meshheading:1530890-Chromosomes, Human, Pair 1,
pubmed-meshheading:1530890-Cloning, Molecular,
pubmed-meshheading:1530890-DNA,
pubmed-meshheading:1530890-Humans,
pubmed-meshheading:1530890-Molecular Sequence Data,
pubmed-meshheading:1530890-Nucleic Acid Hybridization,
pubmed-meshheading:1530890-Oligodeoxyribonucleotides,
pubmed-meshheading:1530890-Phosphoglucomutase,
pubmed-meshheading:1530890-Polymerase Chain Reaction,
pubmed-meshheading:1530890-RNA, Messenger,
pubmed-meshheading:1530890-Rabbits,
pubmed-meshheading:1530890-Sequence Alignment
|
|
pubmed:year |
1992
|
|
pubmed:articleTitle |
Phosphoglucomutase 1: complete human and rabbit mRNA sequences and direct mapping of this highly polymorphic marker on human chromosome 1.
|
|
pubmed:affiliation |
Medical Research Council Human Biochemical Genetics Unit, Galton Laboratory, University College London, United Kingdom.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
