| pubmed-article:1530851 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1530851 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:1530851 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:1530851 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:1530851 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:1530851 | lifeskim:mentions | umls-concept:C0178468 | lld:lifeskim |
| pubmed-article:1530851 | lifeskim:mentions | umls-concept:C0457083 | lld:lifeskim |
| pubmed-article:1530851 | lifeskim:mentions | umls-concept:C1705938 | lld:lifeskim |
| pubmed-article:1530851 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:1530851 | lifeskim:mentions | umls-concept:C1527178 | lld:lifeskim |
| pubmed-article:1530851 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1530851 | pubmed:dateCreated | 1992-2-10 | lld:pubmed |
| pubmed-article:1530851 | pubmed:abstractText | We have investigated the T cell receptor V alpha and V beta gene family usage by T lymphocytes infiltrating affected thyroids in patients with autoimmune thyroid disease. We show that the intrathyroidal T lymphocytes from patients (n = 6) with autoimmune thyroid disease display a widespread usage of V beta gene families with an average of 14.4/19 V beta gene families similar to the peripheral T lymphocytes of the same patients. Because we recently reported that the utilization of V alpha gene families is markedly reduced within these mitogen-stimulated intrathyroidal T cell populations, as well as within intact tissue from similar patients (n = 4) (overall mean of 4.0/18 families detected), these results indicate that in thyroids of patients with autoimmune thyroid disease the lymphocytes are selectively accumulating based on their V alpha rather than V beta elements. This preferential hTcR V alpha and widespread V beta gene usage was not mimicked in most 7-d autologous mixed lymphocyte reactions using non-T cell stimulators (n = 6) or EB-virus immortalized autologous B cell lines (n = 3). Hence, the selective V gene utilization by intrathyroidal T cells is likely to be secondary to multiepitopic thyroidal autoantigens activating thyroid infiltrating T cells or to the presence of a superantigenlike thyroidal self-antigen, capable of determining a selective infiltration or activation of a variety of T lymphocytes on the basis of their V alpha gene usage. | lld:pubmed |
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| pubmed-article:1530851 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1530851 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1530851 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:1530851 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1530851 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:1530851 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:1530851 | pubmed:author | pubmed-author:MartinAA | lld:pubmed |
| pubmed-article:1530851 | pubmed:author | pubmed-author:DaviesT FTF | lld:pubmed |
| pubmed-article:1530851 | pubmed:author | pubmed-author:Ben-NunAA | lld:pubmed |
| pubmed-article:1530851 | pubmed:author | pubmed-author:GravelYY | lld:pubmed |
| pubmed-article:1530851 | pubmed:author | pubmed-author:LahatNN | lld:pubmed |
| pubmed-article:1530851 | pubmed:author | pubmed-author:ConcepcionE... | lld:pubmed |
| pubmed-article:1530851 | pubmed:author | pubmed-author:CohenW LWL | lld:pubmed |
| pubmed-article:1530851 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1530851 | pubmed:volume | 89 | lld:pubmed |
| pubmed-article:1530851 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1530851 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1530851 | pubmed:pagination | 157-62 | lld:pubmed |
| pubmed-article:1530851 | pubmed:dateRevised | 2010-9-7 | lld:pubmed |
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| pubmed-article:1530851 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1530851 | pubmed:articleTitle | Evidence for selective accumulation of intrathyroidal T lymphocytes in human autoimmune thyroid disease based on T cell receptor V gene usage. | lld:pubmed |
| pubmed-article:1530851 | pubmed:affiliation | Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029. | lld:pubmed |
| pubmed-article:1530851 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1530851 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1530851 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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