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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1992-2-10
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pubmed:abstractText |
We have investigated the T cell receptor V alpha and V beta gene family usage by T lymphocytes infiltrating affected thyroids in patients with autoimmune thyroid disease. We show that the intrathyroidal T lymphocytes from patients (n = 6) with autoimmune thyroid disease display a widespread usage of V beta gene families with an average of 14.4/19 V beta gene families similar to the peripheral T lymphocytes of the same patients. Because we recently reported that the utilization of V alpha gene families is markedly reduced within these mitogen-stimulated intrathyroidal T cell populations, as well as within intact tissue from similar patients (n = 4) (overall mean of 4.0/18 families detected), these results indicate that in thyroids of patients with autoimmune thyroid disease the lymphocytes are selectively accumulating based on their V alpha rather than V beta elements. This preferential hTcR V alpha and widespread V beta gene usage was not mimicked in most 7-d autologous mixed lymphocyte reactions using non-T cell stimulators (n = 6) or EB-virus immortalized autologous B cell lines (n = 3). Hence, the selective V gene utilization by intrathyroidal T cells is likely to be secondary to multiepitopic thyroidal autoantigens activating thyroid infiltrating T cells or to the presence of a superantigenlike thyroidal self-antigen, capable of determining a selective infiltration or activation of a variety of T lymphocytes on the basis of their V alpha gene usage.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1530851-1693015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1530851-1700423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1530851-1702377,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1530851-1706524,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1530851-1716476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1530851-1829139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1530851-1971424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1530851-2186745,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1530851-2433339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1530851-2462609,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1530851-2479030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1530851-2521300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1530851-2880865,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1530851-2899600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1530851-3077247,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1530851-3257970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1530851-3311478,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1530851-3485488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1530851-3874876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1530851-6165588,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1530851-6195260
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
89
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
157-62
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1530851-Autoantibodies,
pubmed-meshheading:1530851-Autoimmune Diseases,
pubmed-meshheading:1530851-Base Sequence,
pubmed-meshheading:1530851-Blotting, Southern,
pubmed-meshheading:1530851-Gene Amplification,
pubmed-meshheading:1530851-Graves Disease,
pubmed-meshheading:1530851-Humans,
pubmed-meshheading:1530851-Leukocytes, Mononuclear,
pubmed-meshheading:1530851-Lymphocyte Culture Test, Mixed,
pubmed-meshheading:1530851-Molecular Sequence Data,
pubmed-meshheading:1530851-Oligonucleotides,
pubmed-meshheading:1530851-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:1530851-Ribonucleotides,
pubmed-meshheading:1530851-T-Lymphocyte Subsets,
pubmed-meshheading:1530851-Thyroid Diseases,
pubmed-meshheading:1530851-Thyroid Neoplasms,
pubmed-meshheading:1530851-Thyroiditis, Autoimmune
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pubmed:year |
1992
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pubmed:articleTitle |
Evidence for selective accumulation of intrathyroidal T lymphocytes in human autoimmune thyroid disease based on T cell receptor V gene usage.
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pubmed:affiliation |
Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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