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pubmed-article:15307912pubmed:abstractTextLiver toxicity is a common side effect of antiretroviral therapy, particularly in subjects coinfected with the hepatitis C virus (HCV). The incidence of severe liver toxicity after initiation of treatment with lopinavir (LPV) as well as its possible association with LPV plasma levels were assessed in 120 HIV-infected patients (52% coinfected by HCV). The incidence of severe liver toxicity at 3 months was 1.7% and the cumulative incidence at 12 months was 4%. The development of severe liver toxicity was associated with HCV coinfection but not with LPV plasma levels.lld:pubmed
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pubmed-article:15307912pubmed:dateRevised2011-11-17lld:pubmed
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pubmed-article:15307912pubmed:articleTitleShort communication: liver toxicity of lopinavir-containing regimens in HIV-infected patients with or without hepatitis C coinfection.lld:pubmed
pubmed-article:15307912pubmed:affiliationService of Infectious Diseases and Pharmacy Unit, Hospital Carlos III, 28035 Madrid, Spain.lld:pubmed
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