Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2004-8-12
pubmed:abstractText
The native extracellular matrix (ECM) of elastic tissues is strong and flexible and supports cell adhesion and enzymatic matrix remodeling. In an attempt to convey these ECM properties to a synthetic scaffold appropriate for soft tissue engineering applications, a biodegradable, elastomeric poly(ester urethane)urea (PEUU) was combined with type I collagen at various ratios (2.5, 5, 10, 20, 50, 60, 70, 80, and 90 wt% collagen) and electrospun to construct elastic matrices. Randomly orientated fibers in the electrospun matrices ranged in diameter from 100-900 nm, dependent on initial polymer concentration. Picrosirius red staining of matrices and CD spectroscopy of released collagen confirmed collagen incorporation and preservation of collagen structure at the higher collagen mass fractions. Matrices were strong and distensible possessing strengths of 2-13 MPa with breaking strains of 160-280% even with low PEUU content. Collagen incorporation significantly enhanced smooth muscle cell adhesion onto electrospun scaffolds. An approach has been demonstrated that mimics elastic extracellular matrices by using a synthetic component to provide mechanical function together with a biomacromolecule, collagen. Such matrices may find application in engineering soft tissue.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/15307165-10205057, http://linkedlifedata.com/resource/pubmed/commentcorrection/15307165-10504698, http://linkedlifedata.com/resource/pubmed/commentcorrection/15307165-10923287, http://linkedlifedata.com/resource/pubmed/commentcorrection/15307165-11071603, http://linkedlifedata.com/resource/pubmed/commentcorrection/15307165-11135186, http://linkedlifedata.com/resource/pubmed/commentcorrection/15307165-11192376, http://linkedlifedata.com/resource/pubmed/commentcorrection/15307165-11749726, http://linkedlifedata.com/resource/pubmed/commentcorrection/15307165-11886649, http://linkedlifedata.com/resource/pubmed/commentcorrection/15307165-11888306, http://linkedlifedata.com/resource/pubmed/commentcorrection/15307165-11948520, http://linkedlifedata.com/resource/pubmed/commentcorrection/15307165-12115475, http://linkedlifedata.com/resource/pubmed/commentcorrection/15307165-12486328, http://linkedlifedata.com/resource/pubmed/commentcorrection/15307165-12504511, http://linkedlifedata.com/resource/pubmed/commentcorrection/15307165-12527290, http://linkedlifedata.com/resource/pubmed/commentcorrection/15307165-14580912, http://linkedlifedata.com/resource/pubmed/commentcorrection/15307165-1765652, http://linkedlifedata.com/resource/pubmed/commentcorrection/15307165-7012158, http://linkedlifedata.com/resource/pubmed/commentcorrection/15307165-8169083, http://linkedlifedata.com/resource/pubmed/commentcorrection/15307165-91593, http://linkedlifedata.com/resource/pubmed/commentcorrection/15307165-9212390, http://linkedlifedata.com/resource/pubmed/commentcorrection/15307165-9358314
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1549-3296
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
70
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
603-14
pubmed:dateRevised
2011-9-5
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Fabrication of biodegradable elastomeric scaffolds with sub-micron morphologies.
pubmed:affiliation
Department of Chemical Engineering, 100 Technology Drive, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't