Source:http://linkedlifedata.com/resource/pubmed/id/15306695
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2004-8-12
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| pubmed:abstractText |
The incidence and severity of obesity and type 2 diabetes are increasing in Western societies. The progression of obesity to type 2 diabetes is gradual with overlapping symptoms of insulin resistance, hyperinsulinemia, hyperglycemia, dyslipidemias, ion imbalance, and inflammation; this complex syndrome has been called diabesity. We describe here comparisons of gene expression in livers of A/a (agouti) vs. A(vy)/A (obese yellow) segregants (i.e., littermates) from BALB/cStCrlfC3H/Nctr x VYWffC3Hf/Nctr-A(vy)/a matings in response to 70% and 100% of ad libitum caloric intakes of a reproducible diet. Twenty-eight (28) genes regulated by diet, genotype, or diet x genotype interactions mapped to diabesity quantitative trait loci. A subset of the identified genes is linked to abnormal physiological signs observed in obesity and diabetes.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
1531-2267
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:day |
11
|
| pubmed:volume |
18
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
316-24
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| pubmed:dateRevised |
2010-11-18
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| pubmed:meshHeading |
pubmed-meshheading:15306695-Animals,
pubmed-meshheading:15306695-Breeding,
pubmed-meshheading:15306695-Caloric Restriction,
pubmed-meshheading:15306695-Chromosome Mapping,
pubmed-meshheading:15306695-Diet,
pubmed-meshheading:15306695-Energy Intake,
pubmed-meshheading:15306695-Female,
pubmed-meshheading:15306695-Gene Expression Regulation,
pubmed-meshheading:15306695-Genes,
pubmed-meshheading:15306695-Genetic Linkage,
pubmed-meshheading:15306695-Genetic Markers,
pubmed-meshheading:15306695-Genotype,
pubmed-meshheading:15306695-Male,
pubmed-meshheading:15306695-Mice,
pubmed-meshheading:15306695-Mice, Inbred BALB C,
pubmed-meshheading:15306695-Mice, Inbred C3H,
pubmed-meshheading:15306695-Mice, Inbred Strains,
pubmed-meshheading:15306695-Mice, Obese,
pubmed-meshheading:15306695-Obesity,
pubmed-meshheading:15306695-Quantitative Trait Loci,
pubmed-meshheading:15306695-Weight Gain
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
Identification of genes contributing to the obese yellow Avy phenotype: caloric restriction, genotype, diet x genotype interactions.
|
| pubmed:affiliation |
University of California at Davis, Davis, California 95616, USA. jkaput@ucdavis.edu
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|