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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2004-8-12
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pubmed:abstractText |
To identify tumor-suppressor genes on chromosome 10 in non-small cell lung cancers, we isolated 10 types of splicing variant of the HELLS/SMARCA6 gene transcripts. HELLS/SMARCA6 is a novel member of SNF2 family, which is implicated in cellular functions like chromatin remodeling. Variant 1 was an alternatively spliced isoform containing an insertion of a 44 ntd intronic sequence between exons 3 and 4, giving rise to a premature termination of translation. Expression of variant 1 was detected exclusively in lung cancer specimens (11 of 43 cases, 26%) but was not detected in corresponding normal tissues. The D10S520 marker in the proximity of the HELLS/SMARCA6 gene showed prevalent allelic loss (41%) compared to flanking markers (25-31%). These results suggest that loss of function of HELLS/SMARCA6 by allelic loss and aberrant proteins by tumor-specific exon creation may result in epigenetic deregulation, leading lung cells to malignancy or its progression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0020-7136
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pubmed:author |
pubmed-author:IchimuraKoichiK,
pubmed-author:InakiYasuhikoY,
pubmed-author:KobayashiKazuyasuK,
pubmed-author:OuchidaMamoruM,
pubmed-author:ShigematsuHisayukiH,
pubmed-author:ShimizuKenjiK,
pubmed-author:ShimizuNobuyoshiN,
pubmed-author:TanakaNoriyoshiN,
pubmed-author:ToyookaShinichiS,
pubmed-author:TsukudaKazunoriK,
pubmed-author:YanoMasaakiM
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pubmed:copyrightInfo |
Copyright 2004 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
112
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
8-13
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pubmed:dateRevised |
2007-7-24
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pubmed:meshHeading |
pubmed-meshheading:15305370-Adenocarcinoma,
pubmed-meshheading:15305370-Aged,
pubmed-meshheading:15305370-Alternative Splicing,
pubmed-meshheading:15305370-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:15305370-Carcinoma, Squamous Cell,
pubmed-meshheading:15305370-Case-Control Studies,
pubmed-meshheading:15305370-Chromosomes, Human, Pair 10,
pubmed-meshheading:15305370-DNA,
pubmed-meshheading:15305370-DNA Helicases,
pubmed-meshheading:15305370-Disease Progression,
pubmed-meshheading:15305370-Exons,
pubmed-meshheading:15305370-Female,
pubmed-meshheading:15305370-Humans,
pubmed-meshheading:15305370-Immunoenzyme Techniques,
pubmed-meshheading:15305370-Loss of Heterozygosity,
pubmed-meshheading:15305370-Lung Neoplasms,
pubmed-meshheading:15305370-Male,
pubmed-meshheading:15305370-Reverse Transcriptase Polymerase Chain Reaction
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pubmed:year |
2004
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pubmed:articleTitle |
Tumor-specific exon creation of the HELLS/SMARCA6 gene in non-small cell lung cancer.
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pubmed:affiliation |
Department of Surgical Oncology and Thoracic Surgery, Graduate School of Medicine and Dentistry, Okayama University, Okayama, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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