GENERIC 15304634

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0041228, umls-concept:C1524003
pubmed:dateCreated	2004-8-12
pubmed:abstractText	African trypanosomiasis or sleeping sickness is hallmarked by sleep and wakefulness disturbances. In contrast to other infections, there is no hypersomnia, but the sleep pattern is fragmented. This overview discusses that the causative agents, the parasites Trypanosoma brucei, target circumventricular organs in the brain, causing inflammatory responses in hypothalamic structures that may lead to dysfunctions in the circadian-timing and sleep-regulatory systems.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/1-R01-HL-71510-01
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101208185
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Aug
pubmed:issn	1548-9213
pubmed:author	pubmed-author:BentivoglioMarinaM, pubmed-author:KristenssonKristerK, pubmed-author:LundkvistGabriella BGB
pubmed:issnType	Print
pubmed:volume	19
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	198-206
pubmed:dateRevised	2010-1-14
pubmed:meshHeading	pubmed-meshheading:15304634-Animals, pubmed-meshheading:15304634-Disorders of Excessive Somnolence, pubmed-meshheading:15304634-Humans, pubmed-meshheading:15304634-Trypanosoma brucei brucei, pubmed-meshheading:15304634-Trypanosomiasis, African
pubmed:year	2004
pubmed:articleTitle	Why trypanosomes cause sleeping sickness.
pubmed:affiliation	Department of Biology, University of Virginia, Charlottesville, Virginia 22904, USA.
pubmed:publicationType	Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Research Support, Non-U.S. Gov't