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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2004-8-12
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pubmed:abstractText |
The authors recently have shown that triplication of the alpha-synuclein gene (SNCA) can cause Parkinson disease (PD) and diffuse Lewy body disease within the same kindred. The authors assessed 101 familial PD probands, 325 sporadic PD cases, 65 patients with dementia with Lewy bodies, and 366 neurologically normal control subjects for SNCA multiplication. The authors did not identify any subjects with multiplication of SNCA and conclude this mutation is a rare cause of disease.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1526-632X
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pubmed:author |
pubmed-author:CHINW TWT,
pubmed-author:EerolaJJ,
pubmed-author:EvansE WEW,
pubmed-author:GallardoMM,
pubmed-author:GibsonAA,
pubmed-author:Gwinn-HardyKK,
pubmed-author:HansonMM,
pubmed-author:HardyH HHH,
pubmed-author:HardyJJ,
pubmed-author:HellstromOO,
pubmed-author:HernandezD GDG,
pubmed-author:JarosEE,
pubmed-author:JohnsonJJ,
pubmed-author:McInerney-LeoAA,
pubmed-author:McKeithI GIG,
pubmed-author:MorrisC MCM,
pubmed-author:NussbaumR LRL,
pubmed-author:PerryR HRH,
pubmed-author:RavinaBB,
pubmed-author:RyuMM,
pubmed-author:SingletonA AAA,
pubmed-author:SingletonA BAB,
pubmed-author:TienariPP,
pubmed-author:WeiserRR,
pubmed-author:WilsonK EKE
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pubmed:issnType |
Electronic
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pubmed:day |
10
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
554-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15304594-Adult,
pubmed-meshheading:15304594-Aged,
pubmed-meshheading:15304594-Aged, 80 and over,
pubmed-meshheading:15304594-Cohort Studies,
pubmed-meshheading:15304594-DNA Mutational Analysis,
pubmed-meshheading:15304594-England,
pubmed-meshheading:15304594-European Continental Ancestry Group,
pubmed-meshheading:15304594-Family Health,
pubmed-meshheading:15304594-Female,
pubmed-meshheading:15304594-Finland,
pubmed-meshheading:15304594-Gene Dosage,
pubmed-meshheading:15304594-Gene Duplication,
pubmed-meshheading:15304594-Gene Expression Regulation,
pubmed-meshheading:15304594-Genetic Predisposition to Disease,
pubmed-meshheading:15304594-Hispanic Americans,
pubmed-meshheading:15304594-Humans,
pubmed-meshheading:15304594-Lewy Body Disease,
pubmed-meshheading:15304594-Male,
pubmed-meshheading:15304594-Middle Aged,
pubmed-meshheading:15304594-Nerve Tissue Proteins,
pubmed-meshheading:15304594-Parkinson Disease,
pubmed-meshheading:15304594-Synucleins,
pubmed-meshheading:15304594-United States,
pubmed-meshheading:15304594-alpha-Synuclein
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pubmed:year |
2004
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pubmed:articleTitle |
SNCA multiplication is not a common cause of Parkinson disease or dementia with Lewy bodies.
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pubmed:affiliation |
Laboratory of Neurogenetics, National Institute on Aging, NIH, Bethesda, MD 20892, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study
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