Linked Life Data

15304206

Source:http://linkedlifedata.com/resource/pubmed/id/15304206

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2004-8-12
pubmed:abstractText
During early development, the eutherian mammalian embryo forms a blastocyst comprising an outer trophectoderm epithelium and enclosed inner cell mass (ICM). The short-term goal of blastocyst morphogenesis, including epithelial differentiation and segregation of the ICM, is mainly regulated autonomously and comprises a combination of temporally controlled gene expression, cell polarisation, differentiative cell divisions and cell-cell interactions. This aspect of blastocyst biogenesis is reviewed, focusing, in particular, on the maturation and role of cell adhesion systems. Early embryos are also sensitive to their environment, which can affect their developmental potential in diverse ways and may lead to long-term consequences relating to fetal or postnatal growth and physiology. Some current concepts of embryo-environment interactions, which may impact on future health, are also reviewed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
1031-3613
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
325-37
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Society for Reproductive Biology Founders' Lecture 2003. The making of an embryo: short-term goals and long-term implications.
pubmed:affiliation
Division of Cell Sciences, School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton, UK. tpf@soton.ac.uk
pubmed:publicationType
Research Support, Non-U.S. Gov't, Lectures