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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2004-8-17
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pubmed:abstractText |
Infection with Listeria monocytogenes causes lymphocyte apoptosis that is mediated by the actions of the pore-forming virulence factor listeriolysin O (LLO). Previous work showed that activated lymphocytes were highly sensitive to LLO-induced apoptosis, whereas resting lymphocytes were less susceptible. We now show that mice deficient in the type I interferon (IFN) receptor were more resistant to Listeria infection and had less apoptotic lesions than wild-type counterparts. Furthermore, treatment of resting splenic lymphocytes with recombinant IFN-alphaA enhanced their susceptibility to LLO-induced apoptosis. Together, these data suggest that type I IFN signaling is detrimental to handling of a bacterial pathogen and may enhance the susceptibility of lymphocytes undergoing apoptosis in response to bacterial pore-forming toxins.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15302900-10209048,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15302900-10510340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15302900-10646605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15302900-10899025,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15302900-11420042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15302900-12356687,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15302900-12359878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15302900-12444163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15302900-12461569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15302900-12871639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15302900-12872134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15302900-14634115,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15302900-15067065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15302900-3084667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15302900-3086456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15302900-8009221,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15302900-8456300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15302900-8456301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15302900-8825279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15302900-9120398,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15302900-9284827,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15302900-9314070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15302900-9466984,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15302900-9858519
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
200
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
535-40
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:15302900-Animals,
pubmed-meshheading:15302900-Apoptosis,
pubmed-meshheading:15302900-Bacterial Toxins,
pubmed-meshheading:15302900-CD4-Positive T-Lymphocytes,
pubmed-meshheading:15302900-Eosine Yellowish-(YS),
pubmed-meshheading:15302900-Heat-Shock Proteins,
pubmed-meshheading:15302900-Hematoxylin,
pubmed-meshheading:15302900-Hemolysin Proteins,
pubmed-meshheading:15302900-In Situ Nick-End Labeling,
pubmed-meshheading:15302900-Interferon Type I,
pubmed-meshheading:15302900-Listeriosis,
pubmed-meshheading:15302900-Mice,
pubmed-meshheading:15302900-Mice, Mutant Strains,
pubmed-meshheading:15302900-Receptors, Interferon,
pubmed-meshheading:15302900-Signal Transduction,
pubmed-meshheading:15302900-Spleen
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pubmed:year |
2004
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pubmed:articleTitle |
Type I interferon sensitizes lymphocytes to apoptosis and reduces resistance to Listeria infection.
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pubmed:affiliation |
Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Ave., St. Louis, MO 63110, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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