|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
15
|
|
pubmed:dateCreated |
2004-8-10
|
|
pubmed:abstractText |
The additive effects of combined valsartan and spironolactone on plasma and cardiac aldosterone escape were evaluated in spontaneously hypertensive rats (SHRs). Twenty-four SHRs were treated with valsartan (30 mg/kg body weight per day), spironolactone (20 mg/kg body weight per day) and a combination of both for 4 months. Blood was collected and plasma aldosterone (PA) was estimated with radioimmunoassay (RIA). Ex vivo heart perfusion was performed, the ex vivo cardiac aldosterone (EXCA) was assessed by RIA after high-performance liquid chromatography separation. PA and EXCA were significantly decreased after one month but increased after 4 months in valsartan administration group. The combined valsartan and spironolactone therapy normalized cardiac aldosterone levels. This study provides the first evidence that the long-term treatment with Angiotensin II type 1 receptor antagonist (AT1A) induces local aldosterone escape in cardiovascular tissue, whereas the combined AT1A and spironolactone therapy inhibits the escape in hypertensive rats.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0024-3205
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
27
|
|
pubmed:volume |
75
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1871-8
|
|
pubmed:dateRevised |
2004-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:15302230-Aldosterone,
pubmed-meshheading:15302230-Aldosterone Antagonists,
pubmed-meshheading:15302230-Animals,
pubmed-meshheading:15302230-Antihypertensive Agents,
pubmed-meshheading:15302230-Blood Pressure,
pubmed-meshheading:15302230-Body Weight,
pubmed-meshheading:15302230-Central Venous Pressure,
pubmed-meshheading:15302230-Chromatography, High Pressure Liquid,
pubmed-meshheading:15302230-Collagen,
pubmed-meshheading:15302230-Heart,
pubmed-meshheading:15302230-Hydroxyproline,
pubmed-meshheading:15302230-Male,
pubmed-meshheading:15302230-Myocardium,
pubmed-meshheading:15302230-Organ Size,
pubmed-meshheading:15302230-Rats,
pubmed-meshheading:15302230-Rats, Inbred SHR,
pubmed-meshheading:15302230-Renin-Angiotensin System,
pubmed-meshheading:15302230-Spironolactone,
pubmed-meshheading:15302230-Tetrazoles,
pubmed-meshheading:15302230-Valine
|
|
pubmed:year |
2004
|
|
pubmed:articleTitle |
Additive effects of combined valsartan and spironolactone on cardiac aldosterone escape in spontaneously hypertensive rats.
|
|
pubmed:affiliation |
Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan city, Hubei province, 430060, PR China. ejintian@yahoo.com.cn
|
|
pubmed:publicationType |
Journal Article
|
