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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2004-8-10
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pubmed:abstractText |
These studies characterize a molecule known as regeneration and tolerance factor (RTF), which controls inflammation by regulating interleukin 1 beta (IL-1 beta) secretion. Recently, it has been demonstrated that the interaction of adenosine triphosphate (ATP) with the P2X7 purinoceptor induces the secretion of IL-1 beta and initiates the inflammatory response. In these experiments, that the addition of ATP to macrophages was found to induce P2X7 activation and secretion of IL-1 beta. This secretion is enhanced with anti-RTF antibody in combination with exogenous ATP (p< 0.005). RTF is also revealed to be able to influence surface ATPase activity and, increase PI incorporation, which is an indicator of P2X7 activation. We demonstrate that RTF has a role in controlling IL-1 beta secretion by regulating P2X7 activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Triphosphatases,
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Triphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/P2RX7 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Propidium,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Purinergic P2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Purinergic P2X7,
http://linkedlifedata.com/resource/pubmed/chemical/Regeneration and tolerance factor...,
http://linkedlifedata.com/resource/pubmed/chemical/Suppressor Factors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Trypan Blue
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0198-8859
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
65
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
676-82
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:15301855-Adenosine Triphosphatases,
pubmed-meshheading:15301855-Adenosine Triphosphate,
pubmed-meshheading:15301855-Antibodies, Monoclonal,
pubmed-meshheading:15301855-Blotting, Western,
pubmed-meshheading:15301855-Cell Line,
pubmed-meshheading:15301855-Cell Membrane Permeability,
pubmed-meshheading:15301855-Cell Survival,
pubmed-meshheading:15301855-Coculture Techniques,
pubmed-meshheading:15301855-Dose-Response Relationship, Drug,
pubmed-meshheading:15301855-Flow Cytometry,
pubmed-meshheading:15301855-Humans,
pubmed-meshheading:15301855-Interferon-gamma,
pubmed-meshheading:15301855-Interleukin-1,
pubmed-meshheading:15301855-Leukocytes, Mononuclear,
pubmed-meshheading:15301855-Lipopolysaccharides,
pubmed-meshheading:15301855-Macrophages,
pubmed-meshheading:15301855-Propidium,
pubmed-meshheading:15301855-Receptors, Purinergic P2,
pubmed-meshheading:15301855-Receptors, Purinergic P2X7,
pubmed-meshheading:15301855-Suppressor Factors, Immunologic,
pubmed-meshheading:15301855-Trypan Blue
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pubmed:year |
2004
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pubmed:articleTitle |
Regeneration and tolerance factor modulates the effect of adenosine triphosphate-induced interleukin 1 beta secretion in human macrophages.
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pubmed:affiliation |
Department of Microbiology and Immunology, Finch University of Health Sciences, The Chicago Medical School, North Chicago, IL 60064, USA.
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pubmed:publicationType |
Journal Article
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