rdf:type |
|
lifeskim:mentions |
umls-concept:C0005684,
umls-concept:C0016360,
umls-concept:C0021745,
umls-concept:C0036667,
umls-concept:C0040083,
umls-concept:C0041904,
umls-concept:C0162493,
umls-concept:C0312418,
umls-concept:C0334227,
umls-concept:C1280500,
umls-concept:C1627358,
umls-concept:C2349975
|
pubmed:issue |
8
|
pubmed:dateCreated |
2004-8-10
|
pubmed:abstractText |
Platelet-derived endothelial cell growth factor/thymidine phosphorylase (PD-ECGF/TP) is an essential enzyme in converting 5'-deoxy-5-fluorouridine (5'-DFUR), and 5-fluorouracil (5-FU) to their active metabolites in vivo, and can be up-regulated by some cytokines such as interleukin-1, and interferon gamma (INFgamma). This study was to observe the regulative effect of INFgamma on expression of PD-ECGF/TP, and its relation with the anti-cancer effect of 5'-DFUR, and 5-FU on RT4 bladder cancer cells.
|
pubmed:language |
chi
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Aug
|
pubmed:issn |
1000-467X
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
23
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
929-32
|
pubmed:dateRevised |
2008-11-21
|
pubmed:meshHeading |
pubmed-meshheading:15301717-Antineoplastic Agents,
pubmed-meshheading:15301717-Cell Line, Tumor,
pubmed-meshheading:15301717-Drug Synergism,
pubmed-meshheading:15301717-Floxuridine,
pubmed-meshheading:15301717-Fluorouracil,
pubmed-meshheading:15301717-Humans,
pubmed-meshheading:15301717-Interferon-gamma,
pubmed-meshheading:15301717-RNA, Messenger,
pubmed-meshheading:15301717-Thymidine Phosphorylase,
pubmed-meshheading:15301717-Up-Regulation,
pubmed-meshheading:15301717-Urinary Bladder Neoplasms
|
pubmed:year |
2004
|
pubmed:articleTitle |
[Enhancement effect of interferon gamma on the sensitivity of RT4 bladder cancer cells to 5'-deoxy-5-fluorouridine,and 5-fluorouracil through up-regulation of PD-ECGF/TP].
|
pubmed:affiliation |
Department of Urology, The First Affiliated Hospital, Suzhou University, Suzhou, Jiangsu, 215006, PR China. ligang8882000@yahoo.com.cn
|
pubmed:publicationType |
Journal Article,
English Abstract
|