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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2004-8-10
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pubmed:abstractText |
So that reinforcing and subjective effects of methylphenidate as a function of dose and level of sleepiness could be evaluated, 21 volunteers received methylphenidate (5, 10, or 20 mg) or placebo on 2 sampling days. After 4 and 8 hr time in bed (TIB), they chose their preferred capsule on 5 days. Methylphenidate was chosen more frequently after 4 hr TIB (60%) than it was after 8 hr TIB (33%). The strongest preference (68%) was seen in the 10-mg group. At 10 and 20 mg, stimulant-like subjective effects were reported. The 10-mg group was more adversely affected by the restricted bedtime and showed more pronounced drug effects with methylphenidate. These results indicate that sleepiness modulates the reinforcing and subjective effects of methylphenidate.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1064-1297
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
180-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15301635-Adult,
pubmed-meshheading:15301635-Arousal,
pubmed-meshheading:15301635-Beds,
pubmed-meshheading:15301635-Central Nervous System Stimulants,
pubmed-meshheading:15301635-Choice Behavior,
pubmed-meshheading:15301635-Demography,
pubmed-meshheading:15301635-Dose-Response Relationship, Drug,
pubmed-meshheading:15301635-Double-Blind Method,
pubmed-meshheading:15301635-Drug Administration Schedule,
pubmed-meshheading:15301635-Drug Evaluation,
pubmed-meshheading:15301635-Female,
pubmed-meshheading:15301635-Humans,
pubmed-meshheading:15301635-Male,
pubmed-meshheading:15301635-Methylphenidate,
pubmed-meshheading:15301635-Middle Aged,
pubmed-meshheading:15301635-Outcome Assessment (Health Care),
pubmed-meshheading:15301635-Pain Measurement,
pubmed-meshheading:15301635-Reinforcement (Psychology),
pubmed-meshheading:15301635-Reinforcement Schedule,
pubmed-meshheading:15301635-Sleep,
pubmed-meshheading:15301635-Time Factors
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pubmed:year |
2004
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pubmed:articleTitle |
Reinforcing and subjective effects of methylphenidate: dose and time in bed.
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pubmed:affiliation |
Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, MI 48202, USA. TARoehrs@aol.com
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Randomized Controlled Trial
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