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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2004-8-9
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pubmed:abstractText |
Smad-regulated transcription plays a central role in transforming growth factor (TGF)-beta-induced cell growth inhibition and tumor suppression. Like the Smads, KLF11 is an early response transcription factor that mediates TGF-beta-induced growth inhibition in untransformed epithelial cells. Here, we investigated the functional implications of KLF11 in TGF-beta signaling and transcription in normal epithelial as well as pancreatic cancer cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/KLF11 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/SIN3A transcription factor,
http://linkedlifedata.com/resource/pubmed/chemical/Smad2 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Smad7 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/ras Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0016-5085
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
127
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
607-20
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pubmed:dateRevised |
2011-6-7
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pubmed:meshHeading |
pubmed-meshheading:15300592-Animals,
pubmed-meshheading:15300592-CHO Cells,
pubmed-meshheading:15300592-COS Cells,
pubmed-meshheading:15300592-Carcinoma, Pancreatic Ductal,
pubmed-meshheading:15300592-Cell Cycle Proteins,
pubmed-meshheading:15300592-Cricetinae,
pubmed-meshheading:15300592-DNA-Binding Proteins,
pubmed-meshheading:15300592-Epithelial Cells,
pubmed-meshheading:15300592-GC Rich Sequence,
pubmed-meshheading:15300592-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:15300592-MAP Kinase Signaling System,
pubmed-meshheading:15300592-Mitogen-Activated Protein Kinases,
pubmed-meshheading:15300592-Nuclear Proteins,
pubmed-meshheading:15300592-Pancreatic Neoplasms,
pubmed-meshheading:15300592-Phosphorylation,
pubmed-meshheading:15300592-Promoter Regions, Genetic,
pubmed-meshheading:15300592-Repressor Proteins,
pubmed-meshheading:15300592-Smad2 Protein,
pubmed-meshheading:15300592-Smad7 Protein,
pubmed-meshheading:15300592-Trans-Activators,
pubmed-meshheading:15300592-Transcription, Genetic,
pubmed-meshheading:15300592-Transcription Factors,
pubmed-meshheading:15300592-Transforming Growth Factor beta,
pubmed-meshheading:15300592-ras Proteins
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pubmed:year |
2004
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pubmed:articleTitle |
KLF11 mediates a critical mechanism in TGF-beta signaling that is inactivated by Erk-MAPK in pancreatic cancer cells.
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pubmed:affiliation |
Department of Internal Medicine, University of Ulm, Germany. volker.ellenrieder@medizin.uni-ulm.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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