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pubmed-article:15300198pubmed:abstractTextThe inhibition of nitric oxide (NO) by hypercholesterolemia may be mediated, in part, by interactions with caveolin-1 (Cav-1). Because of the facilitatory effects of statins on endothelial function and the adverse effects of rapamycin (RAPA) on plasma lipids, we compared the effects of simvastatin (SMV) and RAPA on endothelial NO synthase (eNOS) and Cav-1 protein expression and phosphorylation in the aortas of apolipoprotein E (Apo-E) knockout (-/-) mice.lld:pubmed
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pubmed-article:15300198pubmed:copyrightInfoCopyright 2004 Elsevier Inc.lld:pubmed
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pubmed-article:15300198pubmed:articleTitleAortic eNOS expression and phosphorylation in Apo-E knockout mice: differing effects of rapamycin and simvastatin.lld:pubmed
pubmed-article:15300198pubmed:affiliationDepartment of Surgery, University of Texas Medical Branch at Galveston, TX 77555, USA.lld:pubmed
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