rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2004-8-9
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pubmed:abstractText |
The inhibition of nitric oxide (NO) by hypercholesterolemia may be mediated, in part, by interactions with caveolin-1 (Cav-1). Because of the facilitatory effects of statins on endothelial function and the adverse effects of rapamycin (RAPA) on plasma lipids, we compared the effects of simvastatin (SMV) and RAPA on endothelial NO synthase (eNOS) and Cav-1 protein expression and phosphorylation in the aortas of apolipoprotein E (Apo-E) knockout (-/-) mice.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins E,
http://linkedlifedata.com/resource/pubmed/chemical/Cav1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Caveolin 1,
http://linkedlifedata.com/resource/pubmed/chemical/Caveolins,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type III,
http://linkedlifedata.com/resource/pubmed/chemical/Nos3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Simvastatin,
http://linkedlifedata.com/resource/pubmed/chemical/Sirolimus
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0039-6060
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2004 Elsevier Inc.
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pubmed:issnType |
Print
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pubmed:volume |
136
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
323-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15300198-Animals,
pubmed-meshheading:15300198-Aorta,
pubmed-meshheading:15300198-Apolipoproteins E,
pubmed-meshheading:15300198-Caveolin 1,
pubmed-meshheading:15300198-Caveolins,
pubmed-meshheading:15300198-Cholesterol,
pubmed-meshheading:15300198-Endothelial Cells,
pubmed-meshheading:15300198-Immunohistochemistry,
pubmed-meshheading:15300198-Male,
pubmed-meshheading:15300198-Mice,
pubmed-meshheading:15300198-Mice, Knockout,
pubmed-meshheading:15300198-Nitric Oxide Synthase,
pubmed-meshheading:15300198-Nitric Oxide Synthase Type II,
pubmed-meshheading:15300198-Nitric Oxide Synthase Type III,
pubmed-meshheading:15300198-Phosphorylation,
pubmed-meshheading:15300198-Simvastatin,
pubmed-meshheading:15300198-Sirolimus
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pubmed:year |
2004
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pubmed:articleTitle |
Aortic eNOS expression and phosphorylation in Apo-E knockout mice: differing effects of rapamycin and simvastatin.
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pubmed:affiliation |
Department of Surgery, University of Texas Medical Branch at Galveston, TX 77555, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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