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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2004-8-9
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pubmed:abstractText |
SEG-1, a Barrett's-derived esophageal adenocarcinoma cell line, is not responsive to transforming growth factor beta (TGF-beta) growth effects. We hypothesize that SEG-1 cells lack the tumor-suppressor gene Runt domain transcription factor 3 (RUNX3) and that its reinstatement can restore the antiproliferative and apoptotic effects of TGF-beta.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0039-6060
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2004 Elsevier Inc.
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pubmed:issnType |
Print
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pubmed:volume |
136
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
310-6
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15300196-Adenocarcinoma,
pubmed-meshheading:15300196-Animals,
pubmed-meshheading:15300196-Apoptosis,
pubmed-meshheading:15300196-COS Cells,
pubmed-meshheading:15300196-Cell Division,
pubmed-meshheading:15300196-Cell Line, Tumor,
pubmed-meshheading:15300196-Core Binding Factor Alpha 3 Subunit,
pubmed-meshheading:15300196-DNA-Binding Proteins,
pubmed-meshheading:15300196-Esophageal Neoplasms,
pubmed-meshheading:15300196-Humans,
pubmed-meshheading:15300196-Transcription Factors,
pubmed-meshheading:15300196-Transforming Growth Factor beta
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pubmed:year |
2004
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pubmed:articleTitle |
RUNX3 inhibits cell proliferation and induces apoptosis by reinstating transforming growth factor beta responsiveness in esophageal adenocarcinoma cells.
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pubmed:affiliation |
Department of Surgery, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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