Linked Life Data

15299830

Source:http://linkedlifedata.com/resource/pubmed/id/15299830

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
Pt 4
pubmed:dateCreated
2004-8-9
pubmed:abstractText
When a small biologically active molecule enters the body it has the possibility of interacting with one or many of the large variety of macromolecules that are present. This interaction involves a unique complementary fit between the two that depends not only on the shape, but also on the distribution of charges on the surfaces of both [Fischer (1894). Ber. Dtsch. Chem. Ges. 27, 2984-993]. This recognition between two molecules may elicit a biological response and such processes are the subject of biochemical investigations. The question asked here is: what geometrical information on distances and relative orientations of interacting non-bonded functional groups can be found from X-ray crystallographic investigations?
pubmed:language
eng
pubmed:journal
pubmed:status
PubMed-not-MEDLINE
pubmed:month
Jul
pubmed:issn
0907-4449
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
418-27
pubmed:dateRevised
2007-7-24
pubmed:year
1995
pubmed:articleTitle
Intermolecular interactions around functional groups in crystals: data for modeling the binding of drugs to biological macromolecules.
pubmed:affiliation
The Institute for Cancer Research, The Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
pubmed:publicationType
Journal Article