Linked Life Data

15298760

Source:http://linkedlifedata.com/resource/pubmed/id/15298760

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2004-8-9
pubmed:abstractText
A Chlorella powder was screened using 52 in vitro assay systems for enzyme activity, receptor binding, cellular cytokine release, and B and T cell proliferation. The screening revealed a very potent inhibition of human protein tyrosine phosphatase (PTP) activity of CD45 and PTP1C with 50% inhibitory concentration (IC(50)) values of 0.678 and 1.56 microg/mL, respectively. It also showed a moderate inhibition of other PTPs, including PTP1B (IC(50) = 65.3 microg/mL) and T-cell-PTP (114 microg/mL). Other inhibitory activities and their IC(50) values included inhibition of the human matrix metalloproteinases (MMPs) MMP-1 (127 microg/mL), MMP-3 (185 microg/mL), MMP-7 (18.1 microg/mL), and MMP-9 (237 microg/mL) and the human peptidase caspases caspase 1 (300 microg/mL), caspase 3 (203 microg/mL), caspase 6 (301 microg/mL), caspase 7 (291 microg/mL), and caspase 8 (261 microg/mL), as well as release of the cytokines interleukin (IL)-1 (44.9 microg/mL), IL-2 (14.8 microg/mL), IL-4 (49.2 microg/mL), IL-6 (34.7 microg/mL), interferon-gamma (31.6 microg/mL), and tumor necrosis factor-alpha (11 microg/mL) from human peripheral blood mononuclear cells. Chlorella also inhibited B cell proliferation (16.6 microg/mL) in mouse splenocytes and T cell proliferation (54.2 microg/mL) in mouse thymocytes. The binding of a phorbol ester, phorbol 12,13-dibutyrate, to its receptors was also inhibited by Chlorella with an IC(50) of 152 microg/mL. These results reveal potential pharmacological activities that, if confirmed by in vivo studies, might be exploited for the prevention or treatment of several serious pathologies, including inflammatory disease and cancer.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1096-620X
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
146-52
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:15298760-Animals, pubmed-meshheading:15298760-Antigens, CD45, pubmed-meshheading:15298760-B-Lymphocytes, pubmed-meshheading:15298760-Caspases, pubmed-meshheading:15298760-Chlorella, pubmed-meshheading:15298760-Concanavalin A, pubmed-meshheading:15298760-Cytokines, pubmed-meshheading:15298760-Enzyme Inhibitors, pubmed-meshheading:15298760-Humans, pubmed-meshheading:15298760-Lipopolysaccharides, pubmed-meshheading:15298760-Lymphocyte Activation, pubmed-meshheading:15298760-Matrix Metalloproteinases, pubmed-meshheading:15298760-Mice, pubmed-meshheading:15298760-Mice, Inbred BALB C, pubmed-meshheading:15298760-Mice, Inbred ICR, pubmed-meshheading:15298760-Protein Kinase C, pubmed-meshheading:15298760-Protein Tyrosine Phosphatases, pubmed-meshheading:15298760-Receptors, Drug, pubmed-meshheading:15298760-T-Lymphocytes
pubmed:year
2004
pubmed:articleTitle
Effects of chlorella on activities of protein tyrosine phosphatases, matrix metalloproteinases, caspases, cytokine release, B and T cell proliferations, and phorbol ester receptor binding.
pubmed:affiliation
MDS Pharma Services Taiwan Ltd., 158 Li-Teh Road, Taipei 112, Taiwan, Republic of China. fong-chi.cheng@mdsps.com
pubmed:publicationType
Journal Article