rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
4
|
pubmed:dateCreated |
2004-8-9
|
pubmed:abstractText |
Sensory neuropathy in diabetic patients frequently presents itself as progressive loss of thermal perception, while some patients describe concurrent spontaneous pain, allodynia or hyperalgesia. Diabetic rats develop thermal hypoalgesia and tactile allodynia by unknown mechanisms. We investigated whether sensory disorders in rats were related to glucose metabolism by aldose reductase. We also explored the therapeutic potential of exogenous neurotrophic factors.
|
pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
|
pubmed:issn |
0012-186X
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
47
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
718-24
|
pubmed:dateRevised |
2011-11-17
|
pubmed:meshHeading |
pubmed-meshheading:15298349-Aldehyde Reductase,
pubmed-meshheading:15298349-Animals,
pubmed-meshheading:15298349-Body Weight,
pubmed-meshheading:15298349-Brain-Derived Neurotrophic Factor,
pubmed-meshheading:15298349-Ciliary Neurotrophic Factor,
pubmed-meshheading:15298349-Diabetes Mellitus, Experimental,
pubmed-meshheading:15298349-Diabetic Neuropathies,
pubmed-meshheading:15298349-Enzyme Inhibitors,
pubmed-meshheading:15298349-Female,
pubmed-meshheading:15298349-Hot Temperature,
pubmed-meshheading:15298349-Hypoglycemic Agents,
pubmed-meshheading:15298349-Insulin,
pubmed-meshheading:15298349-Pain Measurement,
pubmed-meshheading:15298349-Rats,
pubmed-meshheading:15298349-Rats, Sprague-Dawley,
pubmed-meshheading:15298349-Sensation Disorders,
pubmed-meshheading:15298349-Sensory Thresholds
|
pubmed:year |
2004
|
pubmed:articleTitle |
Prevention of sensory disorders in diabetic Sprague-Dawley rats by aldose reductase inhibition or treatment with ciliary neurotrophic factor.
|
pubmed:affiliation |
Department of Pathology, University of California, San Diego, La Jolla 92093-0612, USA. ncalcutt@ucsd.edu
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|