Linked Life Data

15297631

Source:http://linkedlifedata.com/resource/pubmed/id/15297631

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2004-9-24
pubmed:abstractText
Transforming growth factor-beta (TGF-beta) is a growth factor/cytokine involved in vascular remodeling and atherogenesis. Recent studies in apolipoprotein E-deficient mice have demonstrated a pivotal role of TGF-beta in the maintenance of the balance between inflammation and fibrosis in atherosclerotic plaques. Furthermore, inhibition of TGF-beta signaling has been shown to accelerate plaque formation and its progression toward an unstable phenotype in mice. However, if this mechanism is operative also in humans is still unknown. The aim of this study was to characterize the expression of TGF-beta1 in human carotid plaque and to correlate it with the extent of inflammatory infiltration and collagen content with the clinical signs of plaque instability.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1524-4628
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2253-7
pubmed:dateRevised
2007-4-24
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Increased expression of transforming growth factor-beta1 as a stabilizing factor in human atherosclerotic plaques.
pubmed:affiliation
Department of Medicine and Aging, School of Medicine, and Aging Research Center, Ce.S.I. Gabriele d'Annunzio University Foundation, Chieti-Pescara, Italy. fcipollone@unich.it
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't