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rdf:type |
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lifeskim:mentions |
umls-concept:C0017715,
umls-concept:C0020615,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0026809,
umls-concept:C0027651,
umls-concept:C0205054,
umls-concept:C0599781,
umls-concept:C1327616,
umls-concept:C1527148,
umls-concept:C1704689,
umls-concept:C1880177,
umls-concept:C2349975
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pubmed:issue |
11
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pubmed:dateCreated |
2004-10-18
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pubmed:abstractText |
Mice bearing IL-1beta-secreting tumor were used to study the chronic effect of IL-1beta on glucose metabolism. Mice were injected with syngeneic tumor cells transduced with the human IL-1beta gene. Serum IL-1beta levels increased exponentially with time. Secretion of IL-1beta from the developed tumors was associated with decreased food consumption, reduced body weight, and reduced blood glucose levels. Body composition analysis revealed that IL-1beta caused a significant loss in fat tissue without affecting lean body mass and water content. Hepatic phosphoenolpyruvate carboxykinase and glucose-6-phosphatase activities and mRNA levels of these enzymes were reduced, and 2-deoxy-glucose uptake by peripheral tissues was enhanced. mRNA levels of glucose transporters (Gluts) in the liver were determined by real-time PCR analysis. Glut-3 mRNA levels were up-regulated by IL-1beta. Glut-1 and Glut-4 mRNA levels in IL-1beta mice were similar to mRNA levels in pair-fed mice bearing nonsecreting tumor. mRNA level of Glut-2, the major Glut of the liver, was down-regulated by IL-1beta. We concluded that both decreased glucose production by the liver and enhanced glucose disposal lead to the development of hypoglycemia in mice bearing IL-1beta-secreting tumor. The observed changes in expression of hepatic Gluts that are not dependent on insulin may contribute to the increased glucose uptake.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/C-Peptide,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose-6-Phosphatase,
http://linkedlifedata.com/resource/pubmed/chemical/Glycogen,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoglycemic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Leptin,
http://linkedlifedata.com/resource/pubmed/chemical/Monosaccharide Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/phosphoenolpyruvate carboxylase...
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0013-7227
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
145
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5150-6
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:15297440-Animals,
pubmed-meshheading:15297440-Anorexia,
pubmed-meshheading:15297440-Blood Glucose,
pubmed-meshheading:15297440-Body Composition,
pubmed-meshheading:15297440-Body Weight,
pubmed-meshheading:15297440-C-Peptide,
pubmed-meshheading:15297440-Cell Line, Tumor,
pubmed-meshheading:15297440-Eating,
pubmed-meshheading:15297440-Female,
pubmed-meshheading:15297440-Fibrosarcoma,
pubmed-meshheading:15297440-Gluconeogenesis,
pubmed-meshheading:15297440-Glucose,
pubmed-meshheading:15297440-Glucose-6-Phosphatase,
pubmed-meshheading:15297440-Glycogen,
pubmed-meshheading:15297440-Humans,
pubmed-meshheading:15297440-Hypoglycemia,
pubmed-meshheading:15297440-Hypoglycemic Agents,
pubmed-meshheading:15297440-Insulin,
pubmed-meshheading:15297440-Interleukin-1,
pubmed-meshheading:15297440-Leptin,
pubmed-meshheading:15297440-Liver,
pubmed-meshheading:15297440-Mice,
pubmed-meshheading:15297440-Mice, Inbred C57BL,
pubmed-meshheading:15297440-Monosaccharide Transport Proteins,
pubmed-meshheading:15297440-Neoplasm Transplantation,
pubmed-meshheading:15297440-Protein-Serine-Threonine Kinases,
pubmed-meshheading:15297440-RNA, Messenger
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pubmed:year |
2004
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pubmed:articleTitle |
Inhibition of hepatic gluconeogenesis and enhanced glucose uptake contribute to the development of hypoglycemia in mice bearing interleukin-1beta- secreting tumor.
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pubmed:affiliation |
Department of Medicine, Hadassah University Hospital, Mount Scopus, P.O. Box 24035, Jerusalem 91240, Israel.
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pubmed:publicationType |
Journal Article
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