| pubmed-article:15296715 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15296715 | lifeskim:mentions | umls-concept:C0044602 | lld:lifeskim |
| pubmed-article:15296715 | lifeskim:mentions | umls-concept:C0285761 | lld:lifeskim |
| pubmed-article:15296715 | lifeskim:mentions | umls-concept:C1368105 | lld:lifeskim |
| pubmed-article:15296715 | lifeskim:mentions | umls-concept:C1451005 | lld:lifeskim |
| pubmed-article:15296715 | lifeskim:mentions | umls-concept:C1705325 | lld:lifeskim |
| pubmed-article:15296715 | lifeskim:mentions | umls-concept:C0015665 | lld:lifeskim |
| pubmed-article:15296715 | lifeskim:mentions | umls-concept:C0004391 | lld:lifeskim |
| pubmed-article:15296715 | lifeskim:mentions | umls-concept:C0013494 | lld:lifeskim |
| pubmed-article:15296715 | lifeskim:mentions | umls-concept:C0013138 | lld:lifeskim |
| pubmed-article:15296715 | lifeskim:mentions | umls-concept:C1150481 | lld:lifeskim |
| pubmed-article:15296715 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:15296715 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:15296715 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:15296715 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:15296715 | lifeskim:mentions | umls-concept:C2728259 | lld:lifeskim |
| pubmed-article:15296715 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:15296715 | pubmed:dateCreated | 2004-8-6 | lld:pubmed |
| pubmed-article:15296715 | pubmed:abstractText | Eukaryotic cells catabolize their own cytoplasm by autophagy in response to amino acid starvation and inductive signals during programmed tissue remodeling and cell death. The Tor and PI3K signaling pathways have been shown to negatively control autophagy in eukaryotes, but the mechanisms that link these effectors to overall animal development and nutritional status in multicellular organisms remain poorly understood. Here, we reveal a complex regulation of programmed and starvation-induced autophagy in the Drosophila fat body. Gain-of-function genetic analysis indicated that ecdysone receptor signaling induces programmed autophagy whereas PI3K signaling represses programmed autophagy. Genetic interaction studies showed that ecdysone signaling downregulates PI3K signaling and that this represents the effector mechanism for induction of programmed autophagy. Hence, these studies link hormonal induction of autophagy to the regulatory function of the PI3K signaling pathway in vivo. | lld:pubmed |
| pubmed-article:15296715 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15296715 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15296715 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15296715 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15296715 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15296715 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15296715 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15296715 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15296715 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15296715 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15296715 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15296715 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15296715 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:15296715 | pubmed:issn | 1534-5807 | lld:pubmed |
| pubmed-article:15296715 | pubmed:author | pubmed-author:StenmarkHaral... | lld:pubmed |
| pubmed-article:15296715 | pubmed:author | pubmed-author:JuhászGáborG | lld:pubmed |
| pubmed-article:15296715 | pubmed:author | pubmed-author:SeglenPer OPO | lld:pubmed |
| pubmed-article:15296715 | pubmed:author | pubmed-author:RustenTor... | lld:pubmed |
| pubmed-article:15296715 | pubmed:author | pubmed-author:BrechAndreasA | lld:pubmed |
| pubmed-article:15296715 | pubmed:author | pubmed-author:SassMiklósM | lld:pubmed |
| pubmed-article:15296715 | pubmed:author | pubmed-author:LindmoKarineK | lld:pubmed |
| pubmed-article:15296715 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15296715 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:15296715 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15296715 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15296715 | pubmed:pagination | 179-92 | lld:pubmed |
| pubmed-article:15296715 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:15296715 | pubmed:meshHeading | pubmed-meshheading:15296715... | lld:pubmed |
| pubmed-article:15296715 | pubmed:meshHeading | pubmed-meshheading:15296715... | lld:pubmed |
| pubmed-article:15296715 | pubmed:meshHeading | pubmed-meshheading:15296715... | lld:pubmed |
| pubmed-article:15296715 | pubmed:meshHeading | pubmed-meshheading:15296715... | lld:pubmed |
| pubmed-article:15296715 | pubmed:meshHeading | pubmed-meshheading:15296715... | lld:pubmed |
| pubmed-article:15296715 | pubmed:meshHeading | pubmed-meshheading:15296715... | lld:pubmed |
| pubmed-article:15296715 | pubmed:meshHeading | pubmed-meshheading:15296715... | lld:pubmed |
| pubmed-article:15296715 | pubmed:meshHeading | pubmed-meshheading:15296715... | lld:pubmed |
| pubmed-article:15296715 | pubmed:meshHeading | pubmed-meshheading:15296715... | lld:pubmed |
| pubmed-article:15296715 | pubmed:meshHeading | pubmed-meshheading:15296715... | lld:pubmed |
| pubmed-article:15296715 | pubmed:meshHeading | pubmed-meshheading:15296715... | lld:pubmed |
| pubmed-article:15296715 | pubmed:meshHeading | pubmed-meshheading:15296715... | lld:pubmed |
| pubmed-article:15296715 | pubmed:meshHeading | pubmed-meshheading:15296715... | lld:pubmed |
| pubmed-article:15296715 | pubmed:meshHeading | pubmed-meshheading:15296715... | lld:pubmed |
| pubmed-article:15296715 | pubmed:meshHeading | pubmed-meshheading:15296715... | lld:pubmed |
| pubmed-article:15296715 | pubmed:meshHeading | pubmed-meshheading:15296715... | lld:pubmed |
| pubmed-article:15296715 | pubmed:meshHeading | pubmed-meshheading:15296715... | lld:pubmed |
| pubmed-article:15296715 | pubmed:meshHeading | pubmed-meshheading:15296715... | lld:pubmed |
| pubmed-article:15296715 | pubmed:meshHeading | pubmed-meshheading:15296715... | lld:pubmed |
| pubmed-article:15296715 | pubmed:meshHeading | pubmed-meshheading:15296715... | lld:pubmed |
| pubmed-article:15296715 | pubmed:meshHeading | pubmed-meshheading:15296715... | lld:pubmed |
| pubmed-article:15296715 | pubmed:meshHeading | pubmed-meshheading:15296715... | lld:pubmed |
| pubmed-article:15296715 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15296715 | pubmed:articleTitle | Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway. | lld:pubmed |
| pubmed-article:15296715 | pubmed:affiliation | Department of Biochemistry, The Norwegian Radium Hospital, Montebello, N-0310 Oslo. | lld:pubmed |
| pubmed-article:15296715 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15296715 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:31271 | entrezgene:pubmed | pubmed-article:15296715 | lld:entrezgene |
| entrez-gene:31666 | entrezgene:pubmed | pubmed-article:15296715 | lld:entrezgene |
| entrez-gene:32001 | entrezgene:pubmed | pubmed-article:15296715 | lld:entrezgene |
| entrez-gene:33203 | entrezgene:pubmed | pubmed-article:15296715 | lld:entrezgene |
| entrez-gene:35540 | entrezgene:pubmed | pubmed-article:15296715 | lld:entrezgene |
| entrez-gene:41957 | entrezgene:pubmed | pubmed-article:15296715 | lld:entrezgene |
| entrez-gene:42132 | entrezgene:pubmed | pubmed-article:15296715 | lld:entrezgene |
| entrez-gene:42446 | entrezgene:pubmed | pubmed-article:15296715 | lld:entrezgene |
| entrez-gene:43991 | entrezgene:pubmed | pubmed-article:15296715 | lld:entrezgene |
| entrez-gene:47396 | entrezgene:pubmed | pubmed-article:15296715 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15296715 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15296715 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15296715 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15296715 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15296715 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15296715 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15296715 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15296715 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15296715 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15296715 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15296715 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15296715 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15296715 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15296715 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15296715 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15296715 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15296715 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15296715 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15296715 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15296715 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15296715 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15296715 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15296715 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15296715 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15296715 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15296715 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15296715 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15296715 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15296715 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15296715 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15296715 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15296715 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15296715 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15296715 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15296715 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15296715 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15296715 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15296715 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15296715 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15296715 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15296715 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15296715 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15296715 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15296715 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15296715 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15296715 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15296715 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15296715 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15296715 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15296715 | lld:pubmed |
