Linked Life Data

15294932

Source:http://linkedlifedata.com/resource/pubmed/id/15294932

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2004-8-5
pubmed:abstractText
CD4(+)CD25(+) regulatory T cells are crucial to the maintenance of tolerance in normal individuals. However, the factors regulating this cell population and its function are largely unknown. Estrogen has been shown to protect against the development of autoimmune disease, yet the mechanism is not known. We demonstrate that estrogen (17-beta-estradiol, E2) is capable of augmenting FoxP3 expression in vitro and in vivo. Treatment of naive mice with E2 increased both CD25(+) cell number and FoxP3 expression level. Further, the ability of E2 to protect against autoimmune disease (experimental autoimmune encephalomyelitis) correlated with its ability to up-regulate FoxP3, as both were reduced in estrogen receptor alpha-deficient animals. Finally, E2 treatment and pregnancy induced FoxP3 protein expression to a similar degree, suggesting that high estrogen levels during pregnancy may help to maintain fetal tolerance. In summary, our data suggest E2 promotes tolerance by expanding the regulatory T cell compartment.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
173
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2227-30
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:15294932-Animals, pubmed-meshheading:15294932-Antigens, CD4, pubmed-meshheading:15294932-DNA-Binding Proteins, pubmed-meshheading:15294932-Encephalomyelitis, Autoimmune, Experimental, pubmed-meshheading:15294932-Estrogen Receptor alpha, pubmed-meshheading:15294932-Estrogens, pubmed-meshheading:15294932-Female, pubmed-meshheading:15294932-Flow Cytometry, pubmed-meshheading:15294932-Forkhead Transcription Factors, pubmed-meshheading:15294932-Immune Tolerance, pubmed-meshheading:15294932-Lymphocyte Activation, pubmed-meshheading:15294932-Mice, pubmed-meshheading:15294932-Pregnancy, pubmed-meshheading:15294932-Receptors, Estrogen, pubmed-meshheading:15294932-Receptors, Interleukin-2, pubmed-meshheading:15294932-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:15294932-T-Lymphocytes
pubmed:year
2004
pubmed:articleTitle
Cutting edge: estrogen drives expansion of the CD4+CD25+ regulatory T cell compartment.
pubmed:affiliation
Department of Neurology, Oregon Health and Science University, and Neuroimmunology Research, Veterans Affairs Medical Center, Portland, OR 97239, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't