Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2004-8-17
pubmed:abstractText
The Hedgehog (Hh) signaling pathway regulates a variety of developmental processes, including vasculogenesis, and can also induce the expression of pro-angiogenic factors in fibroblasts postnatally. Misregulation of the Hh pathway has been implicated in a variety of different types of cancer, including pancreatic and small-cell lung cancer. Recently a putative antagonist of the pathway, Hedgehog-interacting protein (HIP), was identified as a Hh binding protein that is also a target of Hh signaling. We sought to clarify possible roles for HIP in angiogenesis and cancer.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/15294024-10050855, http://linkedlifedata.com/resource/pubmed/commentcorrection/15294024-10373119, http://linkedlifedata.com/resource/pubmed/commentcorrection/15294024-11001067, http://linkedlifedata.com/resource/pubmed/commentcorrection/15294024-11081624, http://linkedlifedata.com/resource/pubmed/commentcorrection/15294024-11311154, http://linkedlifedata.com/resource/pubmed/commentcorrection/15294024-11348463, http://linkedlifedata.com/resource/pubmed/commentcorrection/15294024-11385508, http://linkedlifedata.com/resource/pubmed/commentcorrection/15294024-11395778, http://linkedlifedata.com/resource/pubmed/commentcorrection/15294024-11689883, http://linkedlifedata.com/resource/pubmed/commentcorrection/15294024-11748155, http://linkedlifedata.com/resource/pubmed/commentcorrection/15294024-11807029, http://linkedlifedata.com/resource/pubmed/commentcorrection/15294024-11841368, http://linkedlifedata.com/resource/pubmed/commentcorrection/15294024-11948962, http://linkedlifedata.com/resource/pubmed/commentcorrection/15294024-12044012, http://linkedlifedata.com/resource/pubmed/commentcorrection/15294024-12183421, http://linkedlifedata.com/resource/pubmed/commentcorrection/15294024-12200154, http://linkedlifedata.com/resource/pubmed/commentcorrection/15294024-12615704, http://linkedlifedata.com/resource/pubmed/commentcorrection/15294024-12629553, http://linkedlifedata.com/resource/pubmed/commentcorrection/15294024-12654259, http://linkedlifedata.com/resource/pubmed/commentcorrection/15294024-12860919, http://linkedlifedata.com/resource/pubmed/commentcorrection/15294024-1375931, http://linkedlifedata.com/resource/pubmed/commentcorrection/15294024-14520411, http://linkedlifedata.com/resource/pubmed/commentcorrection/15294024-14520413, http://linkedlifedata.com/resource/pubmed/commentcorrection/15294024-15024045, http://linkedlifedata.com/resource/pubmed/commentcorrection/15294024-3563490, http://linkedlifedata.com/resource/pubmed/commentcorrection/15294024-7693335, http://linkedlifedata.com/resource/pubmed/commentcorrection/15294024-8681379, http://linkedlifedata.com/resource/pubmed/commentcorrection/15294024-8756718, http://linkedlifedata.com/resource/pubmed/commentcorrection/15294024-9349822
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins, http://linkedlifedata.com/resource/pubmed/chemical/HHIP protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Hedgehog Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Hhip protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides..., http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins, http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Proteins, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface, http://linkedlifedata.com/resource/pubmed/chemical/SHH protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators, http://linkedlifedata.com/resource/pubmed/chemical/patched receptors
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1471-2407
pubmed:author
pubmed:issnType
Electronic
pubmed:day
4
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
43
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:15294024-Animals, pubmed-meshheading:15294024-Base Sequence, pubmed-meshheading:15294024-Carrier Proteins, pubmed-meshheading:15294024-Cell Division, pubmed-meshheading:15294024-Down-Regulation, pubmed-meshheading:15294024-Endothelium, Vascular, pubmed-meshheading:15294024-Hedgehog Proteins, pubmed-meshheading:15294024-Humans, pubmed-meshheading:15294024-Intracellular Signaling Peptides and Proteins, pubmed-meshheading:15294024-Leydig Cells, pubmed-meshheading:15294024-Male, pubmed-meshheading:15294024-Membrane Glycoproteins, pubmed-meshheading:15294024-Membrane Proteins, pubmed-meshheading:15294024-Mice, pubmed-meshheading:15294024-Mice, Nude, pubmed-meshheading:15294024-Molecular Sequence Data, pubmed-meshheading:15294024-Neoplasms, pubmed-meshheading:15294024-Neovascularization, Pathologic, pubmed-meshheading:15294024-Neovascularization, Physiologic, pubmed-meshheading:15294024-Proteins, pubmed-meshheading:15294024-RNA, Messenger, pubmed-meshheading:15294024-Receptors, Cell Surface, pubmed-meshheading:15294024-Trans-Activators, pubmed-meshheading:15294024-Transplantation, Heterologous, pubmed-meshheading:15294024-Tumor Cells, Cultured
pubmed:year
2004
pubmed:articleTitle
Hedgehog-interacting protein is highly expressed in endothelial cells but down-regulated during angiogenesis and in several human tumors.
pubmed:affiliation
Department of Gene Therapy, Berlex Laboratories, Inc, Richmond, CA 94806, USA. catherine_olsen@berlex.com
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