Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2004-8-5
pubmed:abstractText
Prospective data to support the hypothesis that corticosteroids are a significant cause of muscle weakness in patients with chronic obstructive pulmonary disease (COPD) are lacking. The authors studied respiratory and quadriceps muscle function, using both volitional techniques and magnetic nerve stimulation, as well as measuring metabolic parameters during incremental cycle ergometry, in 25 stable COPD patients. The forced expiratory volume in one second was 37.6 +/- 21.4% predicted, before and after a 2-week course of o.d. prednisolone 30 mg. Quadriceps strength was also assessed in 15 control patients on two occasions. Only two patients met the British Thoracic Society definition of steroid responsiveness. There was no change either in sniff transdiaphragmatic pressure (pre: 96.8 +/- 19.7 cmH2O; post: 98.6 +/- 22.4 cmH2O) or in twitch transdiaphragmatic pressure elicited by bilateral anterolateral magnetic phrenic-nerve stimulation (pre: 16.8 +/- 9.1 cmH2O; post: 17.9 +/- 10 cmH2O). Quadriceps twitch force did not change significantly either in the steroid group (pre: 9.5 +/- 3.1 kg; post: 8.9 +/- 3.7 kg) or in the control patients (pre: 8.1 +/- 2.7 kg; post: 7.9 +/- 2.2 kg). There were no changes in either peak or isotime ventilatory and metabolic parameters during exercise. In conclusion, in stable patients with chronic obstructive pulmonary disease, a 2-week course of 30 mg prednisolone daily does not cause significant skeletal muscle dysfunction or alter metabolic parameters during exercise.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0903-1936
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
137-42
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:15293616-Adrenal Cortex Hormones, pubmed-meshheading:15293616-Aged, pubmed-meshheading:15293616-Case-Control Studies, pubmed-meshheading:15293616-Exercise Test, pubmed-meshheading:15293616-Female, pubmed-meshheading:15293616-Follow-Up Studies, pubmed-meshheading:15293616-Great Britain, pubmed-meshheading:15293616-Humans, pubmed-meshheading:15293616-Male, pubmed-meshheading:15293616-Middle Aged, pubmed-meshheading:15293616-Muscle, Skeletal, pubmed-meshheading:15293616-Muscle Weakness, pubmed-meshheading:15293616-Musculoskeletal Physiological Phenomena, pubmed-meshheading:15293616-Probability, pubmed-meshheading:15293616-Pulmonary Disease, Chronic Obstructive, pubmed-meshheading:15293616-Reference Values, pubmed-meshheading:15293616-Respiratory Function Tests, pubmed-meshheading:15293616-Respiratory Muscles, pubmed-meshheading:15293616-Risk Assessment, pubmed-meshheading:15293616-Severity of Illness Index
pubmed:year
2004
pubmed:articleTitle
Acute effect of oral steroids on muscle function in chronic obstructive pulmonary disease.
pubmed:affiliation
Respiratory Muscle Laboratory, Royal Brompton Hospital, London, UK. n.hopkinson@ic.ac.uk
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't