Source:http://linkedlifedata.com/resource/pubmed/id/15293508
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2004-8-5
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| pubmed:abstractText |
ELISA test systems were designed on the basis of synthetic peptides (SP) simulating the primary structure of functionally significant epitopes of the respiratory and cyncyntial virus (RCV) F-protein for the purpose of investigating the structure and age-related peculiarities of humoral immunity in respect to separate epitopes of RCV F-protein. One of them (221-232) simulates a part of RCV "virus-neutralizing domain" and another one (479-491) is highly important for the fusion mechanisms. New SP-based ELISA were used to examine pair sera in 159 patients with documented RCV infection including children, aged up to 3 years and 3 to 15, and adults. The activity of anti-RCV antibodies to SP was found to be significantly lower in children aged up to 3 years versus the older children and especially versus the adults. The virus neutralizing and, to a greater extent, fusion-inhibiting activities of antibodies were increasing with age, which collated with the results of detecting the antibodies to SP by immune-enzyme assay. The results testify to synchronism of formation of antibodies to different epitopes of the RCV F-protein. The shaping-up of antibodies with the above SP could denote the protective properties of humoral immunity, which justifies the use of the SP-based ELISA in its analysis, especially, in babies as well as in different-type immunodeficiency and immunopathology conditions.
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| pubmed:language |
rus
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Proteins
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| pubmed:status |
MEDLINE
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| pubmed:issn |
0507-4088
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
49
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
25-9
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:15293508-Adolescent,
pubmed-meshheading:15293508-Adult,
pubmed-meshheading:15293508-Aging,
pubmed-meshheading:15293508-Antibodies, Viral,
pubmed-meshheading:15293508-Antibody Formation,
pubmed-meshheading:15293508-Antigens, Viral,
pubmed-meshheading:15293508-Child,
pubmed-meshheading:15293508-Child, Preschool,
pubmed-meshheading:15293508-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:15293508-Epitopes,
pubmed-meshheading:15293508-Humans,
pubmed-meshheading:15293508-Infant,
pubmed-meshheading:15293508-Neutralization Tests,
pubmed-meshheading:15293508-Peptides,
pubmed-meshheading:15293508-Protein Structure, Tertiary,
pubmed-meshheading:15293508-Respiratory Syncytial Virus, Human,
pubmed-meshheading:15293508-Respiratory Syncytial Virus Infections,
pubmed-meshheading:15293508-Species Specificity,
pubmed-meshheading:15293508-Viral Fusion Proteins,
pubmed-meshheading:15293508-Viral Proteins
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| pubmed:articleTitle |
[The age-related specificity of site-oriented immunity in respiratory-syncytial virus infection].
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| pubmed:publicationType |
Journal Article,
Comparative Study,
English Abstract
|