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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2004-8-4
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pubmed:abstractText |
A new type of degradable biomaterial with bone-inducing capacity was made by combining porous beta-tricalcium phosphate (beta-TCP) with a delivery system for recombinant human bone morphogenetic protein-2 (rhBMP-2). The BMP delivery system consisted of a block copolymer composed of poly-D,L-lactic acid with random insertion of p-dioxanone and polyethylene glycol (PLA-DX-PEG), a known biocompatible and biodegradable material. The efficacy of this biomaterial in terms of its bone-inducing capacity was examined by ectopic bone formation in the dorsal muscles of the mouse. In the beta-TCP implants coated with the PLA-DX-PEG polymer containing more than 0.0025% (w/w) of rhBMP-2, new ectopic bone tissues with marrow were consistently found on the surface of implants. The radiographic density of beta-TCP was diminished in a time-dependent manner. On histological examination, numerous multinucleated osteoclasts with positive tartrate-resistant acid-phosphatase (TRAP) staining were noted on the surface of the beta-TCP. These experimental results indicate that beta-TCP implants coated with synthetic rhBMP-2 delivery system might provide effective artificial bone-graft substitutes with osteoinductive capacity and biodegradable properties. In addition, this type of biomaterial may require less rhBMP-2 to induce significant new bone mass.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/4-dioxanone,
http://linkedlifedata.com/resource/pubmed/chemical/Acid Phosphatase,
http://linkedlifedata.com/resource/pubmed/chemical/BMP2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Bmp2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Protein 2,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Phosphates,
http://linkedlifedata.com/resource/pubmed/chemical/Coated Materials, Biocompatible,
http://linkedlifedata.com/resource/pubmed/chemical/Dioxanes,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Lactic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Polyethylene Glycols,
http://linkedlifedata.com/resource/pubmed/chemical/Polymers,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/beta-tricalcium phosphate,
http://linkedlifedata.com/resource/pubmed/chemical/poly(lactic acid),
http://linkedlifedata.com/resource/pubmed/chemical/recombinant human bone...,
http://linkedlifedata.com/resource/pubmed/chemical/tartrate-resistant acid phosphatase
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1549-3296
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2004 Wiley Periodicals, Inc.
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
70
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
450-8
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15293319-Absorbable Implants,
pubmed-meshheading:15293319-Acid Phosphatase,
pubmed-meshheading:15293319-Animals,
pubmed-meshheading:15293319-Bone Morphogenetic Protein 2,
pubmed-meshheading:15293319-Bone Morphogenetic Proteins,
pubmed-meshheading:15293319-Bone Regeneration,
pubmed-meshheading:15293319-Bone and Bones,
pubmed-meshheading:15293319-Calcium Phosphates,
pubmed-meshheading:15293319-Coated Materials, Biocompatible,
pubmed-meshheading:15293319-Dioxanes,
pubmed-meshheading:15293319-Drug Delivery Systems,
pubmed-meshheading:15293319-Humans,
pubmed-meshheading:15293319-Isoenzymes,
pubmed-meshheading:15293319-Lactic Acid,
pubmed-meshheading:15293319-Male,
pubmed-meshheading:15293319-Mice,
pubmed-meshheading:15293319-Mice, Inbred Strains,
pubmed-meshheading:15293319-Microscopy, Electron, Scanning,
pubmed-meshheading:15293319-Polyethylene Glycols,
pubmed-meshheading:15293319-Polymers,
pubmed-meshheading:15293319-Recombinant Proteins,
pubmed-meshheading:15293319-Surface Properties,
pubmed-meshheading:15293319-Time Factors,
pubmed-meshheading:15293319-Transforming Growth Factor beta
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pubmed:year |
2004
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pubmed:articleTitle |
A new bone-inducing biodegradable porous beta-tricalcium phosphate.
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pubmed:affiliation |
Department of Orthopaedic Surgery, Osaka City University School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585 Japan.
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pubmed:publicationType |
Journal Article
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