Source:http://linkedlifedata.com/resource/pubmed/id/15292355
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
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| pubmed:dateCreated |
2004-8-4
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| pubmed:abstractText |
Nerve growth factor-induced clone B (NGFI-B; NR4A1) and Nur-related factor 1 (Nurr1; NR4A2) are members of NGFI-B family of orphan receptors. We recently demonstrated induction of CYP11B2 (aldosterone synthase) by Nurr1 and NGFI-B, suggesting possible important roles of these transcriptional factors in the regulation of adrenocortical steroidogenesis. Therefore, we immunolocalized Nurr1 and NGFI-B in various human adrenal specimens to study their biological significance. In nonpathological adrenal glands (n = 25), Nurr1 and NGFI-B immunoreactivities were detected at high levels in the fetal definitive zone or postnatal zona glomerulosa. NGFI-B immunoreactivity was increased according to development in the zona fasciculata, reaching a level similar to that in the zona glomerulosa in adult adrenal cortex. In adrenocortical neoplasms (n = 44), Nurr1 immunoreactivity was higher in aldosteronoma than in Cushing's adenoma or adrenocortical carcinoma. NGFI-B immunoreactivity was also higher in aldosteronoma than in adrenocortical carcinoma, but was not significantly different among the types of adenoma. Both Nurr1 and NGFI-B mRNA expressions were correlated with their immunoreactivities in adrenocortical neoplasms (n = 23), and mRNA expression of Nurr1 was significantly (P < 0.0001) associated with that of CYP11B2. These results suggest that the expression of Nurr1 and NGFI-B plays an important role in human adrenal cortex and its neoplasms, including possible regulation of steroidogenesis.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aldosterone Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/NR4A2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Receptor Subfamily 4...,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
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| pubmed:issn |
0021-972X
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| pubmed:author |
pubmed-author:BassettMary HMH,
pubmed-author:HayashiYutakaY,
pubmed-author:LuLiangyingL,
pubmed-author:MikiYasuhiroY,
pubmed-author:MoriyaTakuyaT,
pubmed-author:MurakamiOsamuO,
pubmed-author:RaineyWilliam EWE,
pubmed-author:SasanoHironobuH,
pubmed-author:SuzukiTakashiT,
pubmed-author:YoshikawaYosukeY
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| pubmed:issnType |
Print
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| pubmed:volume |
89
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
4113-8
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| pubmed:dateRevised |
2009-11-19
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| pubmed:meshHeading |
pubmed-meshheading:15292355-Adolescent,
pubmed-meshheading:15292355-Adrenal Cortex,
pubmed-meshheading:15292355-Adrenal Cortex Neoplasms,
pubmed-meshheading:15292355-Adult,
pubmed-meshheading:15292355-Aged,
pubmed-meshheading:15292355-Aldosterone Synthase,
pubmed-meshheading:15292355-Case-Control Studies,
pubmed-meshheading:15292355-Child,
pubmed-meshheading:15292355-Child, Preschool,
pubmed-meshheading:15292355-DNA-Binding Proteins,
pubmed-meshheading:15292355-Humans,
pubmed-meshheading:15292355-Immunohistochemistry,
pubmed-meshheading:15292355-Infant,
pubmed-meshheading:15292355-Infant, Newborn,
pubmed-meshheading:15292355-Middle Aged,
pubmed-meshheading:15292355-Nuclear Receptor Subfamily 4, Group A, Member 2,
pubmed-meshheading:15292355-RNA, Messenger,
pubmed-meshheading:15292355-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15292355-Transcription Factors
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| pubmed:year |
2004
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| pubmed:articleTitle |
Nur-related factor 1 and nerve growth factor-induced clone B in human adrenal cortex and its disorders.
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| pubmed:affiliation |
Department of Pathology, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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