|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0004096,
umls-concept:C0007634,
umls-concept:C0016055,
umls-concept:C0030685,
umls-concept:C0038056,
umls-concept:C0060501,
umls-concept:C0145947,
umls-concept:C0162638,
umls-concept:C0205081,
umls-concept:C0205409,
umls-concept:C0391871,
umls-concept:C0547040,
umls-concept:C0680255,
umls-concept:C1280500,
umls-concept:C1283071,
umls-concept:C1533691,
umls-concept:C1704256,
umls-concept:C1963578
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
2004-8-4
|
|
pubmed:abstractText |
Corticosteroids play an important role in inflammation and remodelling of airways and are considered an important therapeutic target in asthma. Inflammation in asthma is characterized by a dysregulation of eosinophil apoptosis and of markers of airways remodelling. We evaluated the ability of flunisolide to inhibit in vitro the release of metalloproteinases-9 (MMP-9), tissue inhibitor metalloproteinases-1 (TIMP-1), transforming growth factor (TGF-beta) and fibronectin by sputum cells (SC) as well as to induce sputum eosinophil apoptosis.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0105-4538
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
59
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
927-32
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:15291899-Adult,
pubmed-meshheading:15291899-Apoptosis,
pubmed-meshheading:15291899-Asthma,
pubmed-meshheading:15291899-Fibronectins,
pubmed-meshheading:15291899-Fluocinolone Acetonide,
pubmed-meshheading:15291899-Humans,
pubmed-meshheading:15291899-Matrix Metalloproteinase 9,
pubmed-meshheading:15291899-Middle Aged,
pubmed-meshheading:15291899-Sputum,
pubmed-meshheading:15291899-Tissue Inhibitor of Metalloproteinase-1,
pubmed-meshheading:15291899-Transforming Growth Factor beta,
pubmed-meshheading:15291899-Transforming Growth Factor beta1
|
|
pubmed:year |
2004
|
|
pubmed:articleTitle |
In vitro effects of flunisolide on MMP-9, TIMP-1, fibronectin, TGF-beta1 release and apoptosis in sputum cells freshly isolated from mild to moderate asthmatics.
|
|
pubmed:affiliation |
Istituto di Biomedicina e Immunologia Molecolare, Consiglio Nazionale delle Ricerche, Palermo, Italy.
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|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
