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rdf:type |
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lifeskim:mentions |
umls-concept:C0003209,
umls-concept:C0015689,
umls-concept:C0023779,
umls-concept:C0024432,
umls-concept:C0441655,
umls-concept:C0762662,
umls-concept:C1327413,
umls-concept:C1515999,
umls-concept:C1523116,
umls-concept:C1550147,
umls-concept:C1709305
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pubmed:issue |
4
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pubmed:dateCreated |
2004-8-4
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pubmed:abstractText |
Omega-3 lipid pretreatment significantly decreases TNF-alpha production in LPS-stimulated Mphis; however, this response is only a partial inhibition, suggesting that other nonsubstrate- (lipid) dependent mechanisms are involved. The cyclooxygenase (COX)-2 enzyme is principally responsible for lipid metabolism; thus, a selective COX-2 inhibitor (Rofecoxib) would clarify if it is an omega-3 lipid direct effect or a COX-2 enzyme-associated modulated reduction in TNF-alpha. Moreover, potential synergy between omega-3 lipids and selective COX-2 inhibition is postulated.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents...,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2 Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Dinoprostone,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids, Omega-3,
http://linkedlifedata.com/resource/pubmed/chemical/Lactones,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/PTGS2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin-Endoperoxide Synthases,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfones,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/rofecoxib
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pubmed:status |
MEDLINE
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pubmed:issn |
0148-6071
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
232-9; discussion 239-40
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15291404-Animals,
pubmed-meshheading:15291404-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:15291404-Cell Line,
pubmed-meshheading:15291404-Cyclooxygenase 2,
pubmed-meshheading:15291404-Cyclooxygenase 2 Inhibitors,
pubmed-meshheading:15291404-Cyclooxygenase Inhibitors,
pubmed-meshheading:15291404-Dinoprostone,
pubmed-meshheading:15291404-Drug Synergism,
pubmed-meshheading:15291404-Fatty Acids, Omega-3,
pubmed-meshheading:15291404-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:15291404-Humans,
pubmed-meshheading:15291404-Lactones,
pubmed-meshheading:15291404-Lipopolysaccharides,
pubmed-meshheading:15291404-Macrophages,
pubmed-meshheading:15291404-Membrane Proteins,
pubmed-meshheading:15291404-NF-kappa B,
pubmed-meshheading:15291404-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:15291404-Sulfones,
pubmed-meshheading:15291404-Tumor Necrosis Factor-alpha
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pubmed:articleTitle |
Synergistic anti-inflammatory activity of omega-3 lipid and rofecoxib pretreatment on macrophage proinflammatory cytokine production occurs via divergent NF-kappaB activation.
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pubmed:affiliation |
Department of Surgery, University of Illinois at Chicago, Chicago, Illinois 60612, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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